NDLI: Immunocytochemical localization of calcium-binding proteins, calbindin D28K-, calretinin-, and parvalbumin-containing neurons in the dog visual cortex.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yu, Song-Hee Lee, Jea-Young Jeon, Chang-Jin
Description	Country affiliation: South Korea Author Affiliation: Yu SH ( Department of Biology, College of Natural Sciences, and Brain Science and Engineering Institute, Kyungpook National University, Daegu, 702-701, South Korea.)
Abstract	Although the dog is widely used to analyze the function of the brain, it is not known whether the distribution of calcium-binding proteins reflects a specific pattern in the visual cortex. The distribution of neurons containing calcium-binding proteins, calbindin D28K, calretinin, and parvalbumin in adult dog visual cortex were studied using immunocytochemistry. We also compared this labeling to that of gamma-aminobutyric acid (GABA). Calbindin D28K-immunoreactive (IR) neurons were predominantly located in layer II/III. Calretinin- and parvalbumin-IR neurons were located throughout the layers with the highest density in layers II/III and IV. The large majority of calbindin D28K-IR neurons were multipolar stellate cells. The majority of the calretinin-IR neurons were vertical fusiform cells with long processes traveling perpendicular to the pial surface. And the large majority of parvalbumin-IR neurons were multipolar stellate and round/oval cells. More than 90% of the calretinin- and parvalbumin-IR neurons were double-labeled with GABA, while approximately 66% of the calbindin D28K-IR neurons contained GABA. This study elucidates the neurochemical structure of calcium-binding proteins. These data will be informative in appreciating the functional significance of different laminar distributions of calcium-binding proteins between species and the differential vulnerability of calcium-binding proteins-containing neurons, with regard to calcium-dependent excitotoxic procedures.
File Format	HTM / HTML
ISSN	02890003
Issue Number	9
Volume Number	28
Journal	Zoological Science
Language	English
Publisher	Zoological Society of Japan
Publisher Date	2011-09-01
Publisher Place	Japan
Access Restriction	Subscribed
Subject Keyword	Discipline Zoology Dogs Metabolism Neurons Parvalbumins S100 Calcium Binding Protein G Visual Cortex Cytology Animals Calbindin 2 Calbindins Gene Expression Regulation Physiology Immunohistochemistry Genetics Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology

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