NDLI: Are isolated anti-HBc blood donors in high risk group? The detection of HBV DNA in isolated anti-HBc cases with nucleic acid amplification test (NAT) based on transcription-mediated amplification (TMA) and HBV discrimination.

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Are isolated anti-HBc blood donors in high risk group? The detection of HBV DNA in isolated anti-HBc cases with nucleic acid amplification test (NAT) based on transcription-mediated amplification (TMA) and HBV discrimination.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Altunay, Hüsnü Kosan, Erdogan Birinci, Ilhan Aksoy, Armagan Kirali, Kaan Saribas, Suat Aslan, Mustafa Yuksel, Pelin Alan, Esra Yenen, Osman Sadi Kocazeybek, Bekir
Description	Country affiliation: Turkey Author Affiliation: Altunay H ( Capa, Red Crescent Blood Center, Istanbul, Turkey.)
Abstract	AIM: Hepatitis B virus (HBV) can be transmitted by blood transfusions even so using serological tests having high sensitivity and specificity. We aimed to detect HBV DNA in isolated Anti-HBc donors and show if they have transfusion risk or not. METHOD: We investigated Anti-Hbc and Anti-HBs in serum samples of 12858 HBs-Ag negative blood donors who were applied to the Turkish Redcrescent between June 2007 and October 2008 by the Micro ELISA kit (Hepanostica ultra HBsAg, Bio Meriux, France). Anti-HBc and Anti-Hbs positive cases were omitted. We used Procleix ultrio (Chiro, USA) test kit (Chiron Tigris automated instrument was used) based TMA (Transcription-Mediated Amplification) for NAT study in Anti-HBc positive and Anti-HBs negative plasma samples. The discrimination of HBV in NAT positive samples were performed by Procleix Discrimination (Chiro, USA) test. RESULTS: 2748 (21.4%) Anti-HBc seropositivity were detected in 12852 HBsAg(-) serum samples. 23.5% Anti-HBs negativity was detected in 2748 Anti-HBc positive serum samples. On the other hand, 5.1% isolated Anti-Hbc positivity [HBsAg(-), Anti-HBc(+), Anti-HBs(-)] were detected in 12852 HBsAg(-) serum samples. 0.091% and 0.047% HBV-DNA positivity were detected in isolated Anti-HBc positive plasma samples and HBsAg(-) plasma samples, respectively. CONCLUSION: As a result, even we have detected one HBV transmission in every 2142 blood transfusion by HBsAg screening tests; we suggest that it is not necessary to add additional tests to detect isolated Anti-HBc for routine purposes in Blood Banking. The reasons are higher negativity rates (99%) of isolated Anti-HBc serum samples and the rejection of blood donors with Anti-HBc positivity.
File Format	HTM / HTML
ISSN	14730502
Issue Number	3
Volume Number	43
Journal	Transfusion and Apheresis Science
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Hematology Dna, Viral Blood Hepatitis B Antibodies Hepatitis B Core Antigens Immunology Hepatitis B Virus Isolation & Purification Hepatitis B Transmission Adolescent Blood Transfusion Adverse Effects Statistics & Numerical Data Female Hepatitis B Surface Antigens Humans Male Middle Aged Nucleic Acid Amplification Techniques Risk Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Hematology

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