NDLI: High frequency of autoimmunization among transfusion-dependent Tunisian thalassaemia patients.

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High frequency of autoimmunization among transfusion-dependent Tunisian thalassaemia patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guirat-Dhouib, N. Mezri, M. Hmida, H. Mellouli, F. Kaabi, H. Ouderni, M. Zouari, B. Hmida, S. Bejaoui, M.
Spatial Coverage	Tunisia
Description	Country affiliation: Tunisia Author Affiliation: Guirat-Dhouib N ( Service d'immuno-hématologie pédiatrique, Centre National de Greffe de moelle osseuse 2, rue Djebel Lakhdar, Bab Saadoun 1006, Tunis, Tunisie. drnawelguirat@yahoo.fr)
Abstract	BACKGROUND: Limited data are available on the frequency of RBC alloimmunization and autoimmunization in transfusion-dependent Tunisian ß thalassaemia patients. MATERIALS AND METHODS: We analyzed the clinical and transfusion records of 130 patients (57 females and 73 males; mean age 119 months; range 12-11 months) with ß thalassaemia major and who had regular blood transfusions for periods ranging from 12 to 311 months. RESULTS: Of the 130 patients, ten (7.7%) developed RBC alloantibodies. The most common alloantibodies were directed against antigens in the Rh systems. Erythrocyte-autoantibodies as determined by a positive direct antiglobulin Coombs test, developed in 52(40%) patients with and without underlying RBC alloantibodies, thereby causing autoimmune haemolytic anaemia in eleven patients (21%). CONCLUSIONS: Autoimmunization to erythrocyte antigens is a frequent complication in patients with ß thalassaemia major. Several factors might have contributed to the high autoimmunization rate observed in this study, including non phenotypic blood exposure and alloantibody formation prior to positive Coombs test.
File Format	HTM / HTML
ISSN	14730502
Issue Number	2
Volume Number	45
Journal	Transfusion and Apheresis Science
Language	English
Publisher	Elsevier
Publisher Date	2011-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Hematology Blood Transfusion Adverse Effects Isoantibodies Blood Thalassemia Immunology Therapy Adolescent Child Child, Preschool Erythrocytes Female Humans Male Platelet Transfusion Tunisia Journal Article
Content Type	Text
Resource Type	Article
Subject	Hematology

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