NDLI: A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma.

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A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma.

Multiplex loss of heterozygosity analysis by using single or very few cells.

t(X;18) reverse transcriptase-polymerase chain reaction demonstrating a variant transcript.

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A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hosaka, Taisuke Nakashima, Yasuaki Kusuzaki, Katsuyuki Murata, Hiroaki Nakayama, Tomitaka Nakamata, Takeharu Aoyama, Tomoki Okamoto, Takeshi Nishijo, Kohichi Araki, Nobuhito Tsuboyama, Tadao Nakamura, Takashi Toguchida, Junya
Description	Country affiliation: Japan Author Affiliation: Hosaka T ( Institute for Frontier Medical Sciences, Department of Orthopedic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan.)
Abstract	Fusion genes consisting of TLS/FUS and CHOP or EWS and CHOP are characteristic markers for myxoid/round cell liposarcomas (MLS/RCLS). Several different structures of the fusion genes were reported in the case of the TLS/FUS-CHOP form, whereas only one type of structure has so far been found for the EWS-CHOP form, which consisted of exons 1 to 7 of the EWS and exons 2 to 4 of the CHOP gene. Here we describe a novel type of EWS-CHOP fusion gene in two cases of MLS/RCLS, which were found in a consecutive analysis of 21 cases. This fusion gene consisted of exons 1 to 10 of the EWS and exons 2 to 4 of the CHOP gene. The two cases with this fusion gene shared several clinical features, such as a large tumor mass, rapid and invasive growth, and local recurrence within 12 months after surgical resection. Histopathological findings also showed common features characterized by the diffuse proliferation of small spindle cells with a primitive mesenchymal appearance. The association of these clinical and histopathological features suggests a distinct biological property for this rare type of fusion product.
File Format	HTM / HTML
ISSN	15251578
e-ISSN	19437811
Journal	The Journal of Molecular Diagnostics
Issue Number	3
Volume Number	4
Language	English
Publisher	Elsevier
Publisher Date	2002-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology Artificial Gene Fusion Ccaat-enhancer-binding Proteins Genetics Liposarcoma, Myxoid Rna-binding Protein Ews Transcription Factors Adolescent Amino Acid Sequence Dna Primers Dna, Neoplasm Pathology Magnetic Resonance Imaging Molecular Sequence Data Reverse Transcriptase Polymerase Chain Reaction Transcription Factor Chop Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Molecular Medicine Pathology and Forensic Medicine

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