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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Newbold, Retha R. Jefferson, Wendy N. Padilla-Banks, Elizabeth |
| Description | Country affiliation: United States Author Affiliation: Newbold RR ( Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. newbold1@niehs.nih.gov) |
| Abstract | The developing fetus is uniquely sensitive to perturbation by chemicals with hormone-like activity. The adverse effects of prenatal diethylstilbestrol (DES) exposure are a classic example. Since concern has been mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical with estrogenic activity used in the synthesis of plastics, we investigated its long-term effects in an experimental animal model that was previously shown useful in studying the adverse effects of developmental exposure to DES. Outbred female CD-1 mice were treated on days 1-5 with subcutaneous injections of BPA (10, 100 or 1000 microg/kg/day) dissolved in corn oil or corn oil alone (Control). At 18 months, ovaries and reproductive tract tissues were examined. There was a statistically significant increase in cystic ovaries and cystic endometrial hyperplasia (CEH) in the BPA-100 group as compared to Controls. Progressive proliferative lesion (PPL) of the oviduct and cystic mesonephric (Wolffian) duct remnants were also seen in all of the BPA groups. More severe pathologies of the uterus following neonatal BPA treatment included adenomyosis, leiomyomas, atypical hyperplasia, and stromal polyps. These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation. |
| File Format | HTM / HTML |
| ISSN | 08906238 |
| e-ISSN | 18731708 |
| Journal | Reproductive Toxicology |
| Issue Number | 2 |
| Volume Number | 24 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2007-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Embryology Discipline Reproductive Medicine Discipline Toxicology Ovary Drug Effects Phenols Toxicity Adenocarcinoma Chemically Induced Pathology Animals Animals, Newborn Animals, Outbred Strains Benzhydryl Compounds Body Weight Corpus Luteum Dose-response Relationship, Drug Endometrial Hyperplasia Endometriosis Estrogens, Non-steroidal Administration & Dosage Injections, Subcutaneous Leiomyoma Mice Ovarian Cysts Oviducts Pregnancy Time Factors Uterine Neoplasms Uterus Research Support, N.i.h., Intramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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