NDLI: Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPAR ) by perfluoroalkyl acids (PFAAs): further investigation of C4-C12 compounds.

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Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPAR ) by perfluoroalkyl acids (PFAAs): further investigation of C4-C12 compounds.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wolf, Cynthia J. Schmid, Judith E. Lau, Christopher Abbott, Barbara D.
Description	Country affiliation: United States Author Affiliation: Wolf CJ ( Developmental Toxicology Branch, Toxicity Assessment Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC 27711, United States. wolf.cynthiaj@epa.gov)
Abstract	Perfluorinated alkyl acids (PFAAs) are manufactured surfactants found globally in the environment and in tissues of humans and wildlife. Several PFAAs adversely affect rodents and activation of PPAR is thought to be their mode of action. Our previous study demonstrated that some PFAAs activate mouse and human PPAR in transiently transfected COS-1 cells. Here, we test more PFAAs for PPAR activation in the same system. Cells were transfected with either mouse or human PPAR -luciferase reporter plasmid, exposed the next day to either vehicle, PPAR agonist (WY14643), perfluoropentanoic acid (C5), perfluoroheptanoic acid (C7), perfluorooctanoic acid (C8), perfluoroundecanoic acid (C11), or perfluorododecanoic acid (C12) at concentrations from 0.5µM to 100µM, and luminescence was measured after 24h. C8 induced the highest activity for human PPAR , followed by C7, C5, and C11. C12 had little activity. C8 induced the highest activity for mouse PPAR , followed by C11, C7, C12 and C5. The two studies together found increasing activity of PPAR with increasing chain length of the PFAA up to perfluorononanoic acid (C9) and lower activity with longer chain PFAAs with both mouse and human PPAR .
File Format	HTM / HTML
ISSN	08906238
Issue Number	4
Volume Number	33
e-ISSN	18731708
Journal	Reproductive Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2012-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Embryology Discipline Reproductive Medicine Discipline Toxicology Environmental Pollutants Chemistry Toxicity Fluorocarbons Ppar Alpha Metabolism Animals Cos Cells Cell Culture Techniques Cell Survival Drug Effects Cercopithecus Aethiops Dose-response Relationship, Drug Humans Linear Models Mice No-observed-adverse-effect Level Genetics Plasmids Species Specificity Structure-activity Relationship Transfection Journal Article Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Toxicology

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Activation of Mouse and Human Peroxisome Proliferator−Activated Receptor Alpha by Perfluoroalkyl Acids of Different Functional Groups and Chain Lengths

Perfluorooctanoic Acid–Induced Developmental Toxicity in the Mouse is Dependent on Expression of Peroxisome Proliferator–Activated Receptor-alpha

Perfluorooctanoate suppresses spheroid attachment on endometrial epithelial cells through peroxisome proliferator-activated receptor alpha and down-regulation of Wnt signaling.

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor in a Ligand-selective Manner.

Activation of Mouse and Human Peroxisome Proliferator–Activated Receptors (α, β/δ, γ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate

Perfluorooctanoic acid induced-developmental cardiotoxicity: are peroxisome proliferator activated receptor (PPAR ) and bone morphorgenic protein 2 (BMP2) pathways involved?

Tri-m-cresyl phosphate and PPAR/LXR interactions in seabream hepatocytes: revealed by computational modeling (docking) and transcriptional regulation of signaling pathways

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues.

Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPAR ) by perfluoroalkyl acids (PFAAs): further investigation of C4-C12 compounds.

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