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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Koen, Emmanuel Besson-Bard, Angélique Duc, Céline Astier, Jérémy Gravot, Antoine Richaud, Pierre Lamotte, Olivier Boucherez, Jossia Gaymard, Frédéric Wendehenne, David |
| Description | Country affiliation: France Author Affiliation: Koen E ( UMR 1347 Agroécologie AgroSup Dijon/INRA/Université de Bourgogne, Pôle Mécanisme et Gestion des Interactions Plantes-microorganismes - ERL CNRS 6300, Dijon, France.) |
| Abstract | The nicotianamine synthase (NAS) enzymes catalyze the formation of nicotianamine (NA), a non-proteinogenic amino acid involved in iron homeostasis. We undertook the functional characterization of AtNAS4, the fourth member of the Arabidopsis thaliana NAS gene family. A mutant carrying a T-DNA insertion in AtNAS4 (atnas4), as well as lines overexpressing AtNAS4 both in the atnas4 and the wild-type genetic backgrounds, were used to decipher the role of AtNAS4 in NA synthesis, iron homeostasis and the plant response to iron deficiency or cadmium supply. We showed that AtNAS4 is an important source for NA. Whereas atnas4 had normal growth in iron-sufficient medium, it displayed a reduced accumulation of ferritins and exhibited a hypersensitivity to iron deficiency. This phenotype was rescued in the complemented lines. Under iron deficiency, atnas4 displayed a lower expression of the iron uptake-related genes IRT1 and FRO2 as well as a reduced ferric reductase activity. Atnas4 plants also showed an enhanced sensitivity to cadmium while the transgenic plants overexpressing AtNAS4 were more tolerant. Collectively, our data, together with recent studies, support the hypothesis that AtNAS4 displays an important role in iron distribution and is required for proper response to iron deficiency and to cadmium supply. |
| File Format | HTM / HTML |
| ISSN | 01689452 |
| Volume Number | 209 |
| e-ISSN | 18732259 |
| Journal | Plant Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-08-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Botany Adaptation, Physiological Genetics Alkyl And Aryl Transferases Arabidopsis Azetidinecarboxylic Acid Analogs & Derivatives Cadmium Metabolism Genes, Plant Iron Deficiency Drug Effects Arabidopsis Proteins Pharmacology Cation Transport Proteins Dna, Bacterial Fmn Reductase Ferritins Gene Expression Gene Expression Regulation, Plant Homeostasis Mutation Phenotype Plants, Genetically Modified Stress, Physiological Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Plant Science Medicine Agronomy and Crop Science |
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