NDLI: Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations.

Please wait, while we are loading the content...

Safety and cost-effectiveness of a clinical protocol implemented to standardize the use of Crotalidae polyvalent immune Fab antivenom at an academic medical center.

Influence of pill burden and drug cost on renal function after transplantation.

Advantages and disadvantages of etomidate use for intubation of patients with sepsis.

Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations.

Plasma renin activity-guided strategy for the management of hypertension.

Klebsiella pneumoniae carbapenemases in Enterobacteriaceae: history, evolution, and microbiology concerns.

Hemopericardium in a patient treated with dabigatran etexilate.

Use of home telehealth monitoring with active medication therapy management by clinical pharmacists in veterans with poorly controlled type 2 diabetes mellitus.

Indacaterol: a novel long-acting ß(2) -agonist.

Immunoassay cross-reactivity of phenylephrine and methamphetamine.

Possible correlation of sirolimus plasma concentration with sinusoidal obstructive syndrome of the liver in patients undergoing myeloablative allogeneic hematopoietic cell transplantation.

Year: 2012 Volume: 32 Issue: 4

Year: 2012 Volume: 32 Issue: 3

Year: 2012 Volume: 32 Issue: 2

Year: 2012 Volume: 32 Issue: 1

Year: 2011 Volume: 31

Year: 2010 Volume: 30

Year: 2009 Volume: 29

Year: 2008 Volume: 28

Year: 2007 Volume: 27

Year: 2006 Volume: 26

Year: 2004 Volume: 24

Year: 2003 Volume: 23

Year: 2002 Volume: 22

Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mehrotra, Nitin Tang, Lisa Phelps, Stephanie J. Meibohm, Bernd
Description	Country affiliation: United States Author Affiliation: Mehrotra N ( Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.)
Abstract	STUDY OBJECTIVE: To compare four common dosing regimens for vancomycin in preterm and term neonates by assessing the probability that each regimen would achieve the widely used therapeutic target serum trough concentrations of 5-15 mg/L and the newly suggested target of 15-20 mg/L. DESIGN: Retrospective population pharmacokinetic analysis using therapeutic drug monitoring data obtained from 1990-2007, with a subsequent simulation study performed on the pharmacokinetic model. SETTING: Tertiary-care children's hospital. PATIENTS: One hundred thirty-four preterm (66%) and term (34%) neonates, with a postnatal age of 1-121 days and postmenstrual age of 24.6-44 weeks. MEASUREMENTS AND MAIN RESULTS: Therapeutic drug monitoring data for vancomycin were used to develop a population pharmacokinetic model in the target population. Parameter estimates for the derived pharmacostatistical model were used to perform Monte Carlo simulations for four recommended dosing regimens: a standard dose for all neonates, postmenstrual age-based dosing, postmenstrual and postnatal age-based dosing, and serum creatinine-based dosing. Multivariate age-weight distributions were established for term and preterm neonates using Centers for Disease Control and Prevention growth charts and intrauterine and postnatal growth charts from the literature, respectively. Each dosing regimen was treated as a separate scenario in which 200 replicates with 100 patients/replicate were simulated. The 5-15-mg/L target trough serum concentration was achieved in 34% (90% confidence interval [CI] 20-53%), 42% (90% CI 31-55%), 52% (90% CI 43-60%), and 63% (90% CI 54-72%) of patients receiving the standard dose, postmenstrual age-based dose, postmenstrual and postnatal age-based dose, and serum creatinine-based dose, respectively. Serum creatinine-based dosing produced trough concentrations predominantly in the 5-15-mg/L target range, with the smallest variability in both term and preterm neonates. As expected, when the target range was narrow and higher (15-20 mg/L), only 13-21% of patients were within the range across the four dosing regimens. CONCLUSION: Monte Carlo simulations based on our population pharmacokinetic model suggest that vancomycin dosing guidelines based on serum creatinine concentration have a greater likelihood of achieving trough concentrations in the 5-15-mg/L range compared with other evaluated dosing regimens. None of the four dosing regimens is suitable to produce target trough concentration of 15-20 mg/L in an acceptable number of patients.
File Format	HTM / HTML
ISSN	02770008
Issue Number	5
Volume Number	32
e-ISSN	18759114
Journal	Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anti-bacterial Agents Drug Monitoring Infant, Premature Blood Models, Biological Vancomycin Administration & Dosage Computer Simulation Creatinine Dose-response Relationship, Drug Drug Administration Schedule Statistics & Numerical Data Gestational Age Humans Infant Infant, Newborn Male Monte Carlo Method Multivariate Analysis Predictive Value Of Tests Retrospective Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Comparative evaluation of six extended-interval gentamicin dosing regimens in premature and full-term neonates.

Gentamicin pharmacokinetics and dosing in neonates with hypoxic ischemic encephalopathy receiving hypothermia.

Once daily dose gentamicin in neonates - is our dosing correct?

Optimization of vancomycin dosing in very low-birth-weight preterm neonates.

Vancomycin prescription in neonates and young infants: toward a simplified dosage.

Darbepoetin Administration in Term and Preterm Neonates.

Low dose lidocaine for refractory seizures in preterm neonates.

Extended interval dosing of gentamicin in premature neonates ≤ 28-week gestation.

Serum calcium values in term and late-preterm neonates receiving gentamicin.

Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations.

Similar Documents

Comparative evaluation of six extended-interval gentamicin dosing regimens in premature and full-term neonates.

Gentamicin pharmacokinetics and dosing in neonates with hypoxic ischemic encephalopathy receiving hypothermia.

Once daily dose gentamicin in neonates - is our dosing correct?

Optimization of vancomycin dosing in very low-birth-weight preterm neonates.

Vancomycin prescription in neonates and young infants: toward a simplified dosage.

Darbepoetin Administration in Term and Preterm Neonates.

Low dose lidocaine for refractory seizures in preterm neonates.

Extended interval dosing of gentamicin in premature neonates ≤ 28-week gestation.

Serum calcium values in term and late-preterm neonates receiving gentamicin.

Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations.