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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lor, Kevin W. Helmons, Pieter J. Belew, Helen Lane, James R. Ball, Edward D. |
| Description | Country affiliation: United States Author Affiliation: Lor KW ( Department of Pharmacy, University of California San Diego Medical Center, San Diego, CA 92103-8765, USA. kloricacid@gmail.com) |
| Abstract | STUDY OBJECTIVE: To describe the institutional experience of plerixafor plus filgrastim as the initial peripheral blood stem cell (PBSC) mobilization (first-line strategy) and as rescue therapy after failure with filgrastim plus cyclophosphamide (second-line strategy). DESIGN: Retrospective medical record review. SETTING: Academic medical center. PATIENTS: Thirty-three patients (median age 62 yrs) who received plerixafor between January 2008 and December 2009. MEASUREMENTS AND MAIN RESULTS: We collected data on total CD34(+) cell yield and number of apheresis sessions in both first-line and second-line plerixafor recipients. Mobilization with plerixafor plus filgrastim resulted in a median yield of 8.95 × 10(6) and 2.45 × 10(6) CD34(+) cells/kg in patients with multiple myeloma or non-Hodgkin's lymphoma, respectively. As rescue mobilization, plerixafor plus filgrastim successfully mobilized CD34(+) cells in 16 (84%) of 19 patients. When comparing first-line plerixafor plus filgrastim therapy with second-line therapy, we found an increase in CD34(+) yield and 1 less apheresis day in patients with multiple myeloma, but no difference in patients with non-Hodgkin's lymphoma. CONCLUSION: A regimen of plerixafor plus filgrastim successfully mobilized CD34(+) cells in a median of 1 apheresis day for patients with multiple myeloma and 2 apheresis days for patients with non-Hodgkin's lymphoma, including patients who failed initial filgrastim plus cyclophosphamide mobilization. Plerixafor plus filgrastim could be a viable first-line option in patients with multiple myeloma, as it improved CD34(+) cell yield and decreased number of apheresis days compared with second-line plerixafor plus filgrastim therapy, whereas it was comparable to second-line therapy in patients with non-Hodgkin's lymphoma. |
| File Format | HTM / HTML |
| ISSN | 02770008 |
| Issue Number | 7 |
| Volume Number | 32 |
| e-ISSN | 18759114 |
| Journal | Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Hematopoietic Stem Cell Mobilization Methods Heterocyclic Compounds Therapeutic Use Lymphoma, Non-hodgkin Therapy Multiple Myeloma Peripheral Blood Stem Cell Transplantation Academic Medical Centers Adult Aged Antigens, Cd34 Metabolism Blood Component Removal Cyclophosphamide Administration & Dosage Drug Therapy, Combination Female Filgrastim Granulocyte Colony-stimulating Factor Humans Male Middle Aged Recombinant Proteins Retrospective Studies Salvage Therapy Transplantation, Autologous Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) |
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