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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vigili de Kreutzenberg, S. Tiengo, A. Avogaro, A. |
| Description | Country affiliation: Italy Author Affiliation: Vigili de Kreutzenberg S ( Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani, 2, 35128 Padova, Italy. saula.dekreutzenberg@unipd.it) |
| Abstract | BACKGROUND AND PURPOSE: Cerebrovascular disease in diabetes appears to be less considered than coronary and peripheral disease, the reason being the intrinsic difficulty in finding available diagnostic tools for its early identification. Among these, carotid artery intima-media thickness (cIMT) represents the simplest measurable parameter for pre-atherosclerotic lesions in extra-cranic arteries. METHODS: The role of cIMT as a surrogate marker of cerebral atherosclerosis and predictor of stroke, its relationship to microangiopathy and chronic inflammation, along with its role as an outcome parameter in anti-hyperglycemic therapeutical intervention trials in type 2 and 1 diabetes mellitus are discussed in this paper. RESULTS AND CONCLUSIONS: Carotid IMT is increased in diabetes. It is an independent predictor of stroke, in particular of the ischemic subtype, and of stroke recurrence in diabetic, as well as in non-diabetic populations. A possible role of cIMT as a predictor of microangiopathy has also been suggested, but it needs further investigation. A weak association with chronic inflammation has been demonstrated in diabetic patients. Carotid IMT has been successfully employed as an outcome parameter for several anti-hyperglycemic therapeutic trials. However data on cIMT as a predictor of cerebrovascular disease are scarce in diabetic patients, particularly in type 1 diabetes, and more studies are needed to define the risk of cerebrovascular disease in diabetic patients. |
| File Format | HTM / HTML |
| ISSN | 09394753 |
| Issue Number | 9 |
| Volume Number | 19 |
| e-ISSN | 15903729 |
| Journal | Nutrition, Metabolism and Cardiovascular Diseases |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Metabolism Discipline Cardiology Discipline Vascular Diseases Discipline Nutritional Sciences Carotid Artery Diseases Epidemiology Pathology Diabetic Angiopathies Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Humans Predictive Value Of Tests Risk Factors Stroke Tunica Intima Tunica Media Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine |
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