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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Hak-Jae Park, Hae Jeong Hong, Mee Sook Song, Jeong Yoon Park, Hyun-Kyung Jo, Dae Jean Park, Sung Wook HwanYun, Dong Park, Hun-Kuk Yang, Jong-Soo Ban, Ju Yeon Chung, Joo-Ho |
| Description | Author Affiliation: Kim HJ ( Kohwang Medical Research Institute, Kyung Hee University, Seoul 130-701, Korea.) |
| Abstract | OBJECTIVES: Early stressors can influence the development of biological and neurological systems. Maternal separation (social isolation) in early life may increase vulnerability to neurodegenerative diseases and neuropsychiatric disorders over the lifespan. To identify new proteins on acupuncture effects in maternally separated rats, an animal model for study of early environmental insults, proteomic approach on the expression of the hypothalamic proteins was performed. METHODS: On post-natal day 14, rat pups were randomly divided into four groups: pups kept with their mothers for 7 days; pups kept with their mothers with acupuncture daily to HT8 (Sobu); maternally separated pups; maternally separated pups with acupuncture. The hypothalamic proteins were analysed by two-dimensional electrophoresis coupled with matrix assisted laser desorption/ionization time-of-flight mass spectrometer. RESULTS: The results showed that 27 spots were differentially and commonly expressed. Of 27 spots, 21 spots were identified while six spots were not, and 15 proteins were known proteins. In maternally separated group, the expressions of 14 proteins were down-regulated, compared to control group. In group of maternally separation with acupuncture, five proteins were down-regulated and nine were up-regulated, compared to the maternally separated group. Among nine proteins up-regulated by acupuncture treatment, we found four proteins (dihydropyrimidinase-like 2, dystrophin-related protein 2, tubulin, alpha 1a and syntaxin 1b) related to neurodevelopment. DISCUSSION: The result suggests that acupuncture to HT8 may affect neurodevelopment, and acupuncture may be a possible therapy for neurodevelopmental disorders. |
| File Format | HTM / HTML |
| ISSN | 01616412 |
| e-ISSN | 17431328 |
| Journal | Neurological Research |
| Issue Number | Suppl 1 |
| Volume Number | 32 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Acupuncture Therapy Hypothalamus Metabolism Maternal Deprivation Stress, Psychological Therapy Animals Body Weight Cytoskeletal Proteins Electrophoresis, Gel, Two-dimensional Intercellular Signaling Peptides And Proteins Membrane Proteins Muscle Proteins Nerve Tissue Proteins Random Allocation Rats, Sprague-dawley Spectrometry, Mass, Matrix-assisted Laser Desorption-ionization Syntaxin 1 Time Factors Tubulin Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) |
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