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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sobrino, Tomás Rodríguez-González, Raquel Blanco, Miguel Brea, David Pérez-Mato, María Rodríguez-Yáñez, Manuel Leira, Rogelio Castillo, José |
| Description | Country affiliation: Spain Author Affiliation: Sobrino T ( Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clínico Universitario, IDIS, University of Santiago de Compostela, Spain.) |
| Abstract | OBJECTIVES: The increase in circulating endothelial progenitor cells (EPCs) is associated with a better outcome in patients with acute ischemic stroke. CDP-choline (citicoline) increases brain plasticity after experimental stroke. Therefore, we study if citicoline treatment could increase the EPC concentration after ischemic stroke. METHODS: Forty-eight patients with a first-ever non-lacunar ischemic stroke were consecutively included in the study within 12 hours of symptoms onset. Patients received treatment (n = 26) or non-treatment (n = 22) with oral citicoline (2000 mg/day) from acute phase of ischemic stroke and for 6 weeks. EPC colonies were quantified as early outgrowth colony forming unit-endothelial cell (CFU-EC) at admission (before citicoline treatment) and day 7. We defined the EPC increment during the first week as the difference in the numbers of CFU-EC between day 7 and admission. RESULTS: CFU-ECs were similar at baseline between patients treated and non-treated with citicoline (7.7±6.1 versus 9.1±7.3 CFU-EC, P = 0.819). However, patients treated with citicoline and recombinant tissue-plasminogen activator (rt-PA) showed a higher EPC increment compared to patients treated only with citicoline or non-treated (35.4±15.9 versus 8.4 ± 8.1 versus 0.9 ± 10.2 CFU-EC, P < 0.0001). In a logistic model, citicoline treatment [odds ratio (OR), 17.6; confidence interval (CI) 95%, 2.3-137.5, P = 0.006] and co-treatment with citicoline and rt-PA (OR, 108.5; CI 95%, 2.9-1094.2, P = 0.001) were independently associated with an EPC increment⩾4 CFU-EC. CONCLUSION: The administration of citicoline and the co-administration of citicoline and rt-PA increase EPC concentration in acute ischemic stroke. |
| File Format | HTM / HTML |
| ISSN | 01616412 |
| e-ISSN | 17431328 |
| Journal | Neurological Research |
| Issue Number | 6 |
| Volume Number | 33 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2011-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Brain Ischemia Drug Therapy Cytidine Diphosphate Choline Therapeutic Use Endothelial Cells Metabolism Stem Cells Stroke Blood Pathology Cell Count Cells, Cultured Pharmacology Drug Effects Prospective Studies Comparative Study Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) |
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