NDLI: Statistical analysis of large-scale neuronal recording data.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reed, Jamie L. Kaas, Jon H.
Description	Country affiliation: United States Author Affiliation: Reed JL ( Department of Psychology, Vanderbilt University, 11121st Ave. S., Nashville, TN 37240, USA. jamie.l.reed@vanderbilt.edu)
Abstract	Relating stimulus properties to the response properties of individual neurons and neuronal networks is a major goal of sensory research. Many investigators implant electrode arrays in multiple brain areas and record from chronically implanted electrodes over time to answer a variety of questions. Technical challenges related to analyzing large-scale neuronal recording data are not trivial. Several analysis methods traditionally used by neurophysiologists do not account for dependencies in the data that are inherent in multi-electrode recordings. In addition, when neurophysiological data are not best modeled by the normal distribution and when the variables of interest may not be linearly related, extensions of the linear modeling techniques are recommended. A variety of methods exist to analyze correlated data, even when the data are not normally distributed and the relationships are nonlinear. Here we review expansions of the Generalized Linear Model designed to address these data properties. Such methods are used in other research fields, and the application to large-scale neuronal recording data will enable investigators to determine the variable properties that convincingly contribute to the variances in the observed neuronal measures. Standard measures of neuron properties such as response magnitudes can be analyzed using these methods, and measures of neuronal network activity such as spike timing correlations can be analyzed as well. We have done just that in recordings from 100-electrode arrays implanted in the primary somatosensory cortex of owl monkeys. Here we illustrate how one example method, Generalized Estimating Equations analysis, is a useful method to apply to large-scale neuronal recordings.
File Format	HTM / HTML
ISSN	08936080
e-ISSN	18792782
DOI	10.1016/j.neunet.2010.04.005
Journal	Neural Networks
Issue Number	6
Volume Number	23
Language	English
Publisher	Elsevier
Publisher Date	2010-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurology Action Potentials Physiology Electrophysiology Statistics & Numerical Data Nerve Net Neurons Neurophysiology Signal Processing, Computer-assisted Animals Aotus Trivirgatus Computer Simulation Instrumentation Linear Models Somatosensory Cortex Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Artificial Intelligence Cognitive Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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