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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Licatalosi, Donny D. Darnell, Robert B. |
| Description | Country affiliation: United States Author Affiliation: Licatalosi DD ( Howard Hughes Medical Institute, Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10021, USA.) |
| Abstract | In recent years views of eukaryotic gene expression have been transformed by the finding that enormous diversity can be generated at the RNA level. Advances in technologies for characterizing RNA populations are revealing increasingly complete descriptions of RNA regulation and complexity; for example, through alternative splicing, alternative polyadenylation and RNA editing. New biochemical strategies to map protein-RNA interactions in vivo are yielding transcriptome-wide insights into mechanisms of RNA processing. These advances, combined with bioinformatics and genetic validation, are leading to the generation of functional RNA maps that reveal the rules underlying RNA regulation and networks of biologically coherent transcripts. Together these are providing new insights into molecular cell biology and disease. |
| File Format | HTM / HTML |
| ISSN | 14710056 |
| e-ISSN | 14710064 |
| DOI | 10.1038/nrg2673 |
| Journal | Nature Reviews Genetics |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Genetics Gene Expression Regulation Gene Regulatory Networks Rna Editing Genetics Alternative Splicing Animals Computational Biology Gene Expression Profiling Genetic Variation Models, Biological Models, Genetic Oligonucleotide Array Sequence Analysis Polyadenylation Transcription, Genetic Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Genetics (clinical) |
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