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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Boehm, Jesse S. Hahn, William C. |
| Description | Country affiliation: United States Author Affiliation: Boehm JS ( Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.) |
| Abstract | Whole-genome approaches to identify genetic and epigenetic alterations in cancer genomes have begun to provide new insights into the range of molecular events that occurs in human tumours. Although in some cases this knowledge immediately illuminates a path towards diagnostic or therapeutic implementation, the bewildering lists of mutations in each tumour make it clear that systematic functional approaches are also necessary to obtain a comprehensive molecular understanding of cancer. Here we review the current range of methods, assays and approaches for genome-scale interrogation of gene function in cancer. We also discuss the integration of functional-genomics approaches with the outputs from cancer genome sequencing efforts. |
| File Format | HTM / HTML |
| ISSN | 14710056 |
| Issue Number | 7 |
| Volume Number | 12 |
| e-ISSN | 14710064 |
| Journal | Nature Reviews Genetics |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2011-06-17 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Genetics Genome, Human Genetics Physiology Genomics Trends Neoplasms Algorithms Animals Databases, Genetic Humans Models, Biological Research Design Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Genetics (clinical) |
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