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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Revill, Peter Testoni, Barbara Locarnini, Stephen Zoulim, Fabien |
| Description | Author Affiliation: Revill P ( Victorian Infectious Disease Reference Laboratory, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010 Australia.); Testoni B ( Cancer Research Center of Lyon, INSERM U1052 and CNRS 5286, Lyon University, and Hospices Civils de Lyon, 151 Cours Albert Thomas, 69003 Lyon, France.); Locarnini S ( Victorian Infectious Disease Reference Laboratory, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010 Australia.); Zoulim F ( Cancer Research Center of Lyon, INSERM U1052 and CNRS 5286, Lyon University, and Hospices Civils de Lyon, 151 Cours Albert Thomas, 69003 Lyon, France.) |
| Abstract | Chronic HBV infection results in >1 million deaths per year from cirrhosis and liver cancer. No known cure for chronic HBV exists, due in part to the continued presence of transcriptionally active DNA in the nucleus that is not directly targeted by current antiviral therapies. A coordinated approach is urgently needed to advance an HBV cure worldwide, such as those established in the HIV field. We propose the establishment of an International Coalition to Eliminate Hepatitis B Virus (ICE-HBV) to facilitate the formation of international working groups on HBV virology, immunology, innovative tools and clinical trials: to promote awareness and education as well as to drive changes in government policy and ensure funds are channelled to HBV cure research and drug development. With the ICE-HBV in place, it should be possible to enable a HBV cure within the next decade. |
| File Format | HTM / HTML |
| ISSN | 17595045 |
| Issue Number | 4 |
| Volume Number | 13 |
| e-ISSN | 17595053 |
| Journal | Nature Reviews Gastroenterology & Hepatology |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2016-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Hepatology Discipline Gastroenterology Antiviral Agents Therapeutic Use Global Health Hepatitis B, Chronic Drug Therapy Prevention & Control International Cooperation Clinical Trials As Topic Economics Drug Discovery Organization & Administration Health Policy Health Promotion Immunology Virology Humans Research Support As Topic Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology |
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