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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bedard, Philippe L. Di Leo, Angelo Piccart-Gebhart, Martine J. |
| Description | Country affiliation: Belgium Author Affiliation: Bedard PL ( Department of Medical Oncology, Jules Bordet Institute, Rue Heger-Bordet 1, Brussels, Belgium.) |
| Abstract | Taxanes are among the most widely used chemotherapy agents for advanced breast cancer. Results are now available from 21 trials that randomly allocated nearly 36,000 women with early-stage breast cancer to receive first-generation taxane-based adjuvant chemotherapy versus non-taxane-based adjuvant regimens. Three recent meta-analyses suggest that taxanes are beneficial in the adjuvant setting, irrespective of the patient's age, lymph-node involvement, hormone-receptor expression, and HER2 status. Nevertheless, the optimal role for taxanes in the adjuvant management of early-stage breast cancer remains controversial. We review the results of the first-generation taxane trials and discuss possible explanations for the differences observed in these studies, including variation in the 'strength' of anthracycline therapy in the control arms; suboptimal timing, dosing, or schedule of the taxane regimen; a masking effect of trials that included patients with relatively chemotherapy-insensitive luminal A disease; and decreased representation of the putative taxane-sensitive disease subset. Inclusion criteria for future clinical trials must be revised to account for the molecular heterogeneity of breast cancer and further optimize the role of adjuvant taxane therapy in early-stage disease. |
| File Format | HTM / HTML |
| ISSN | 17594774 |
| Issue Number | 1 |
| Volume Number | 7 |
| e-ISSN | 17594782 |
| Journal | Nature Reviews Clinical Oncology |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Antineoplastic Agents, Phytogenic Therapeutic Use Breast Neoplasms Drug Therapy Chemotherapy, Adjuvant Taxoids Adult Aged Anthracyclines Administration & Dosage Adverse Effects Antineoplastic Combined Chemotherapy Protocols Tumor Markers, Biological Genetics Pathology Drug Administration Schedule Drug Resistance, Neoplasm Estrogens Female Genetic Heterogeneity Humans Lymphatic Metastasis Meta-analysis As Topic Middle Aged Multicenter Studies As Topic Neoplasm Staging Neoplasms, Hormone-dependent Patient Selection Randomized Controlled Trials As Topic Receptors, Estrogen Analysis Treatment Outcome Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
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