NDLI: Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update.

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Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Takebe, Naoko Miele, Lucio Harris, Pamela Jo Jeong, Woondong Bando, Hideaki Kahn, Michael Yang, Sherry X. Ivy, S. Percy
Description	Country affiliation: United States Author Affiliation: Takebe N ( Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institute of Health, 9609 Medical Center Drive MSC9739, Bethesda, MD 20852, USA.); Miele L ( Stanley Scott Cancer Center, Louisiana State University Health Sciences Center and Louisiana Cancer Research Consortium, USA.); Harris PJ ( Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institute of Health, 9609 Medical Center Drive MSC9739, Bethesda, MD 20852, USA.); Jeong W ( Cancer Therapy and Research Center, University of Texas, USA.); Bando H ( Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Japan.); Kahn M ( Norris Comprehensive Cancer Research Center, University of Southern California, USA.); Yang SX ( National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute, USA.); Ivy SP ( Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institute of Health, 9609 Medical Center Drive MSC9739, Bethesda, MD 20852, USA.)
Abstract	During the past decade, cancer stem cells (CSCs) have been increasingly identified in many malignancies. Although the origin and plasticity of these cells remain controversial, tumour heterogeneity and the presence of small populations of cells with stem-like characteristics is established in most malignancies. CSCs display many features of embryonic or tissue stem cells, and typically demonstrate persistent activation of one or more highly conserved signal transduction pathways involved in development and tissue homeostasis, including the Notch, Hedgehog (HH), and Wnt pathways. CSCs generally have slow growth rates and are resistant to chemotherapy and/or radiotherapy. Thus, new treatment strategies targeting these pathways to control stem-cell replication, survival and differentiation are under development. Herein, we provide an update on the latest advances in the clinical development of such approaches, and discuss strategies for overcoming CSC-associated primary or acquired resistance to cancer treatment. Given the crosstalk between the different embryonic developmental signalling pathways, as well as other pathways, designing clinical trials that target CSCs with rational combinations of agents to inhibit possible compensatory escape mechanisms could be of particular importance. We also share our views on the future directions for targeting CSCs to advance the clinical development of these classes of agents.
File Format	HTM / HTML
ISSN	17594774
e-ISSN	17594782
DOI	10.1038/nrclinonc.2015.61
Journal	Nature Reviews Clinical Oncology
Issue Number	8
Volume Number	12
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-08-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Oncology Hedgehog Proteins Antagonists & Inhibitors Neoplasms Therapy Neoplastic Stem Cells Physiology Receptors, Notch Wnt Signaling Pathway Drug Effects Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Tumor Markers, Biological Metabolism Clinical Trials As Topic Drug Design Drug Resistance, Neoplasm Molecular Targeted Therapy Pathology Signal Transduction
Content Type	Text
Resource Type	Article
Subject	Oncology

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