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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gharwan, Helen Groninger, Hunter |
| Description | Country affiliation: United States Author Affiliation: Gharwan H ( Medical Oncology, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 12N226, Bethesda, Maryland 20892-1906, USA.); Groninger H ( Section of Palliative Care, Department of Medicine, MedStar Washington Hospital Center, 110 Irving Street NW, Room 2A-68, Washington, District of Columbia 20008, USA.) |
| Abstract | Molecularly targeted cancer therapies, such as small-molecule kinase inhibitors and monoclonal antibodies, constitute a rapidly growing and an important part of the oncology armamentarium. Unlike conventional (cytotoxic) chemotherapeutics, targeted therapies were designed to disrupt cancer cell pathogenesis at specific biological points essential for the development and progression of the tumour. These agents were developed to disrupt specific targets with the aim of minimizing treatment burden compared with conventional chemotherapy. Nevertheless the increasingly common use of targeted therapies has revealed some unanticipated, often clinically significant toxic effects, as well as compromising effective palliative and end-of-life management approaches. Although patients and clinicians welcome improvements in cancer prognosis, these changes can also impact patient quality-of-life. Therefore, as demand for oncology expertise increases, physicians need to apprise themselves of targeted therapies and their clinical implications, including drug-specific side effects, impact on quality of life, and cost issues, especially in relation to end-of-life care. This Review provides a useful summary and guide for professionals treating patients with malignant diseases. |
| File Format | HTM / HTML |
| ISSN | 17594774 |
| Issue Number | 4 |
| Volume Number | 13 |
| e-ISSN | 17594782 |
| Journal | Nature Reviews Clinical Oncology |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2016-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Antibodies, Monoclonal Therapeutic Use Antineoplastic Agents Neoplasms Drug Therapy Protein Kinase Inhibitors Pharmacology Disease Management Drug-related Side Effects And Adverse Reactions Classification Diagnosis Humans Molecular Targeted Therapy Adverse Effects Premedication Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
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