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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Camici, Paolo G. D'amati, Giulia Rimoldi, Ornella |
| Description | Country affiliation: Italy Author Affiliation: Camici PG ( Vita Salute University and Scientific Institute San Raffaele, Via Olgettina, 58, 20132 Milano, Italy.); d'Amati G ( Department of Radiology, Oncology and Pathology, 'Sapienza' Università di Roma, Policlinico Umberto I, Viale Regina Elena, 324, 00161 Rome, Italy.); Rimoldi O ( CNR IBFM, Via Fratelli Cervi, 93, 20090 Segrate (MI), Italy.) |
| Abstract | Obstructive disease of the epicardial coronary arteries was recognized as the cause of angina pectoris >2 centuries ago, and sudden thrombotic occlusion of an epicardial coronary artery has been established as the cause of acute myocardial infarction for >100 years. In the past 2 decades, dysfunction of the coronary microvasculature emerged as an additional mechanism of myocardial ischaemia that bears important prognostic implications. The coronary microvasculature (vessels <300 µm in diameter) cannot be directly imaged in vivo, but a number of invasive and noninvasive techniques, each with relative advantages and pitfalls, can be used to assess parameters that depend directly on coronary microvascular function. These methods include invasive or noninvasive measurement of Doppler-derived coronary blood flow velocity reserve, assessment of myocardial blood flow and flow reserve using noninvasive imaging, and calculation of microcirculatory resistance indexes during coronary catheterization. These advanced techniques for assessment of the coronary microvasculature have provided novel insights into the pathophysiological role of coronary microvascular dysfunction in the development of myocardial ischaemia in different clinical conditions. |
| File Format | HTM / HTML |
| ISSN | 17595002 |
| Issue Number | 1 |
| Volume Number | 12 |
| e-ISSN | 17595010 |
| Journal | Nature Reviews Cardiology |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cardiology Coronary Circulation Physiology Coronary Vessels Physiopathology Microcirculation Blood Flow Velocity Echocardiography, Doppler Methods Humans Magnetic Resonance Imaging Positron-emission Tomography Tomography, X-ray Computed Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
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