NDLI: Fractal and image analysis of the microvasculature in normal intestinal submucosa and intestinal polyps in Apc(Min/+) mice.

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Fractal and image analysis of the microvasculature in normal intestinal submucosa and intestinal polyps in Apc(Min/+) mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fuseler, John W. Bedenbaugh, Adam Yekkala, Krishna Baudino, Troy A.
Description	Country affiliation: United States Author Affiliation: Fuseler JW ( Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.)
Abstract	Tumors are supported by the development of a unique vascular bed. We used fractal dimension (Db) and image analysis to quantify differences in the complexity of the vasculature in normal intestinal submucosa and intestinal polyps. Apc(Min/+) mice and wild-type mice were perfused with a curable latex compound, intestines sectioned, and images collected via confocal microscopy. The images were analyzed and area (A), perimeter (P), and integrated optical density (IOD) of the normal and tumor vascular beds were measured. The Db, a quantitative descriptor of morphological complexity, was significantly greater for the polyp vasculature from Apc(Min/+) mice than controls. This indicates that the polyp microvasculature is more chaotic than that of the controls, while the IOD and average vascular density values displayed no differences. This suggests the mass of blood volume is equivalent in normal and polyp microvasculature. The lower vascular area-perimeter ratios expressed by the polyp microvasculature suggest it is composed of smaller, more tortuous vessels. These data demonstrate that fractal analysis is applicable for providing a quantitative description of vascular complexity associated with angiogenesis occurring in normal or diseased tissue. Application of Db, IOD, and average density provides a clearer quantification of the complex morphology associated with tissue microvasculature.
File Format	HTM / HTML
ISSN	14319276
Issue Number	1
Volume Number	16
e-ISSN	14358115
Journal	Microscopy and Microanalysis
Language	English
Publisher	Cambridge University Press
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Chemistry Techniques Image Processing, Computer-assisted Methods Intestinal Mucosa Anatomy & Histology Intestinal Polyps Pathology Microscopy, Confocal Microvessels Animals Mice Mice, Inbred C57bl Neovascularization, Pathologic Neovascularization, Physiologic Journal Article Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Instrumentation

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