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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Yiquan Osei-Adjei, George Ni, Bin Fang, Haihong Zhang, Lingyu Zhao, Xin Huang, Xinxiang Yang, Huiying Yang, Wenhui Sun, Fengjun |
| Description | Country affiliation: China Author Affiliation: Zhang Y ( School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.); Osei-Adjei G ( School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.); Ni B ( School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.); Fang H ( State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100000, China); Zhang L ( School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.); Zhao X ( School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.); Huang X ( School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.); Yang H ( State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100000, China.); Yang W ( State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100000, China. Electronic address: fionyoung@163.com.); Sun F ( Department of Pharmacy, Southwest Hospital, The Third Military Medical University, Chongqing, 400038, China. Electronic address: fengj_sun@163.com.) |
| Abstract | Vibrio parahaemolyticus is a leading cause of seafood-associated diarrhea and gastroenteritis. This bacteria expresses a major virulence determinant called T3SS1. Expression of T3SS1 is tightly regulated by the ExsA-ExsC-ExsD regulatory system. The transcription of exsA and probably exsC is repressed directly by the H-NS protein. In this study, the regulation of exsD by H-NS was investigated using quantitative RT-PCR, primer extension, LacZ fusion, electrophoretic mobility shift, and DNase I footprinting assays. The results showed that His-H-NS protected a single region from 61 bp to 174 bp upstream of exsD against DNase I digestion, and a transcription start site located at 105 bp upstream of exsD was detected and its activity was repressed by H-NS. Therefore, a single H-NS-dependent promoter was transcribed for exsD in V. parahaemolyticus. Thus, all three genes in the ExsA-ExsC-ExsD regulatory system of T3SS1 are directly repressed by H-NS in V. parahaemolyticus. |
| File Format | HTM / HTML |
| ISSN | 08824010 |
| Journal | Microbial Pathogenesis |
| Volume Number | 97 |
| e-ISSN | 10961208 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Discipline Communicable Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Microbiology |
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