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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Goudarzi, Mehdi Seyedjavadi, Sima Sadat Nasiri, Mohammad Javad Goudarzi, Hossein Sajadi Nia, Raheleh Dabiri, Hossein |
| Description | Author Affiliation: Goudarzi M ( Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: gudarzim@yahoo.com.); Seyedjavadi SS ( Department of Medical Mycology, Pasteur Institute of Iran, Tehran, Iran.); Nasiri MJ ( Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.); Goudarzi H ( Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.); Sajadi Nia R ( Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.); Dabiri H ( Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.) |
| Abstract | The widespread emergence of methicillin resistant Staphylococcus aureus, as a common cause of nosocomial infections, is becoming a serious concern in global public health. The objective of the present study was to investigate antimicrobial susceptibility pattern, frequency of virulence genes and molecular characteristics of methicillin-resistant Staphylococcus aureus strains isolated from patients with bacteremia. A total of 128 methicillin-resistant Staphylococcus aureus isolates were collected during February 2015 to January 2016. In vitro antimicrobial susceptibility of the isolates was assessed using the disk diffusion method. Conventional PCR was performed for the detection of adhesion (can, bbp, ebp, fnbB, fnbA, clfB, clfA) and toxin (etb, eta, pvl, tst) encoding genes, determining the agr type, SCCmec, MLST and spa typing of the isolates. All the methicillin-resistant Staphylococcus aureus isolates were found to be sensitive to linezolid, teicoplanin, and vancomycin. Resistance to the tested antibiotics varied from 97.7% for penicillin to 24.2% for mupirocin. The rate of multi drug resistance (MDR) in the present study was 97.7%. The most commonly detected toxin and adhesion genes were tst (58.6%), and clfB (100%), respectively. The majority of SCCmec III isolates were found in agr group I while SCCmec IV and II isolates were distributed among agr group III. Multilocus Sequence Typing (MLST) of the MRSA isolates showed five different sequence types: ST239 (43%), ST22 (39.8%), ST585 (10.9%), ST45 (3.9%) and ST240 (2.3%). All of the pvl positive strains belonged to ST22-SCCmec IV/t790 clone and were MDR. Among different 7 spa types, the most common were t790 (27.3%), t037 (21.9%), and t030 (14.1%). spa types t016, t924 and spa type t383 were reported for the first time from Asia and Iran, respectively. It was shown that spa types circulating in the studied hospitals varied which support the need to perform future surveillance studies in order to understand methicillin-resistant Staphylococcus aureus distribution and thus more effective infection control. |
| File Format | HTM / HTML |
| ISSN | 08824010 |
| Journal | Microbial Pathogenesis |
| Volume Number | 104 |
| e-ISSN | 10961208 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Discipline Communicable Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Microbiology |
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