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The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Konno, Hiroyasu Barber, Glen N.
Description	Country affiliation: United States Author Affiliation: Konno H ( Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL, USA.); Barber GN ( Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL, USA. Electronic address: gbarber@med.miami.edu.)
Abstract	The innate immune system is critically important for the primary sensing of invading pathogens. Over the past decade, the cellular sensors important for recognizing microbial entry into the host cell have been largely elucidated. These sensors, some of which are evolutionarily conserved, include the Toll-like receptor (TLR) and RIG-I-like helicase family (RLH) pathway that can recognize bacterial and viral non-self nucleic acid. In addition, a cellular sensor referred to as STING (for stimulator of interferon genes) has been shown to be critical for triggering host defense countermeasures, including stimulation of the adaptive immune response, following the detection of cytosolic DNA species. The STING pathway has now been shown to be critical for activating innate immune gene transcription in response to infection by DNA pathogens such as herpes simplex virus 1 (HSV1) as well as retroviruses. In addition, it is clear that chronic STING activation can also cause autoinflammatory disease manifested by self-DNA. Here we review recent developments in our understanding of STING function, including importance in the control of microbial disease.
File Format	HTM / HTML
ISSN	12864579
e-ISSN	1769714X
DOI	10.1016/j.micinf.2014.10.002
Journal	Microbes and Infection
Issue Number	12
Volume Number	16
Language	English
Publisher	Elsevier
Publisher Date	2014-12-01
Publisher Place	France
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Immunology Communicable Diseases Immunology Metabolism Host-pathogen Interactions Immunity, Innate Physiology Membrane Proteins Signal Transduction Animals Genetics Cytosol
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology Microbiology

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