NDLI: Comparative in vitro activities of posaconazole, voriconazole, itraconazole, and amphotericin B against Aspergillus and Rhizopus, and synergy testing for Rhizopus.

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Comparative in vitro activities of posaconazole, voriconazole, itraconazole, and amphotericin B against Aspergillus and Rhizopus, and synergy testing for Rhizopus.

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Comparative in vitro activities of posaconazole, voriconazole, itraconazole, and amphotericin B against Aspergillus and Rhizopus, and synergy testing for Rhizopus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Arikan, Sevtap Sancak, Banu Alp, Sehnaz Hascelik, Gulsen McNicholas, Paul
Description	Country affiliation: Turkey Author Affiliation: Arikan S ( Hacettepe University Medical School, Department of Microbiology and Clinical Microbiology, Ankara, Turkey. sevtap.arikan@gmail.com)
Abstract	We compared the in vitro activities of posaconazole, voriconazole, itraconazole, and amphotericin B against clinical isolates of Aspergillus spp. and Rhizopus spp., and explored the in vitro interaction between posaconazole and amphotericin B against Rhizopus spp. Clinical strains of 82 Aspergillus spp. (43 Aspergillus fumigatus, 29 A. flavus, 7 A. niger, 2 A. terreus, 1 A. nidulans) and 11 Rhizopus oryzae isolates were tested in accordance with CLSI M38-A microdilution guidelines. In vitro activity of posaconazole against Aspergillus spp. was also investigated with the Etest. The combination of posaconazole and amphotericin B against R. oryzae isolates was investigated by the checkerboard methodology. Voriconazole was the most active drug in vitro against Aspergillus spp., followed by posaconazole, itraconazole, and amphotericin B, in order of decreasing activity. In studies with R. oryzae isolates, posaconazole was found to be the most potent drug followed by itraconazole and amphotericin B. Voriconazole had no meaningful activity against Rhizopus. Posaconazole Etest MICs (microg/ml) with Aspergillus spp. were found to be considerably lower than those obtained with the CLSI microdilution method (4-9 and 3-7 two-fold lower than CLSI MICs at 24 and 48 h, respectively). The interaction between posaconazole and amphotericin B was indifferent for all R. oryzae isolates tested; importantly no antagonism was observed.
File Format	HTM / HTML
ISSN	13693786
e-ISSN	14602709
Journal	Medical Mycology
Issue Number	6
Volume Number	46
Language	English
Publisher	Oxford University Press
Publisher Date	2008-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Veterinary Medicine Antifungal Agents Pharmacology Aspergillosis Microbiology Aspergillus Drug Effects Mucormycosis Rhizopus Amphotericin B Drug Therapy Genetics Isolation & Purification Drug Synergism Itraconazole Microbial Sensitivity Tests Pyrimidines Triazoles Voriconazole Comparative Study
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary

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