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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Koepsell, Laura Zhang, Lifeng Neufeld, Daniel Fong, Hao Deng, Ying |
| Description | Country affiliation: United States Author Affiliation: Koepsell L ( Biomedical Engineering Program, University of South Dakota, 4800 North Career Avenue, Sioux Falls, SD 57107, USA.) |
| Abstract | The annulus fibrosus comprises concentric lamellae that can be damaged due to intervertebral disc degeneration; to provide permanent repair of these acquired structural defects, one solution is to fabricate scaffolds that are designed to support the growth of annulus fibrosus cells. In this study, electrospun nanofibrous scaffolds of polycaprolactone are fabricated in random, aligned, and round-end configurations. Primary porcine annulus fibrosus cells are grown on the scaffolds and evaluated for attachment, proliferation, and production of extracellular matrix. The scaffold consisting of round-end nanofibers substantially outperforms the random and aligned scaffolds on cell adhesion; additionally, the scaffold with aligned nanofibers strongly affects the orientation of cells. |
| File Format | HTM / HTML |
| ISSN | 16165187 |
| Issue Number | 3 |
| Volume Number | 11 |
| e-ISSN | 16165195 |
| Journal | Macromolecular Bioscience |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2011-03-10 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Intervertebral Disc Physiology Nanofibers Chemistry Polyesters Tissue Engineering Methods Tissue Scaffolds Animals Cell Adhesion Cell Proliferation Collagen Biosynthesis Dna Metabolism Glycosaminoglycans Cytology Microscopy, Fluorescence Ultrastructure Particle Size Porosity Sus Scrofa Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Chemistry Biomaterials Bioengineering Biotechnology Polymers and Plastics |
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