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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Yi Aigner, Achim Agarwal, Seema |
| Description | Country affiliation: Germany Author Affiliation: Zhang Y ( Fb. Chemie, Philipps-Universität Marburg, Hans-Meerwein Strasse 35032, Marburg, Germany.) |
| Abstract | This study describes the synthesis of a set of novel, degradable block copolymers for DNA transfection, and analyzes their physicochemical and biological properties. PEO macro-azoinitiators are used for the free radical copolymerization of DMAEMA and MDO, resulting in a series of different quaternized or non-quaternized block copolymers. All of the polymers show little cytotoxicity and full degradability, and thus, based on their favorable properties, may represent promising vectors for in vivo applications. Marked differences in DNA complexation efficacies and biological activities are observed, and one of the poly(PEG-co-(MDO-co-DMAEMA))s is identified as optimal for DNA transfection. |
| File Format | HTM / HTML |
| ISSN | 16165187 |
| Issue Number | 9 |
| Volume Number | 13 |
| e-ISSN | 16165195 |
| Journal | Macromolecular Bioscience |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2013-09-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Biocompatible Materials Chemistry Dna Metabolism Methacrylates Nylons Transfection Biodegradation, Environmental Calorimetry, Differential Scanning Cell Death Cell Line, Tumor Chromatography, Gel Ethidium Humans Magnetic Resonance Spectroscopy Materials Testing Chemical Synthesis Particle Size Static Electricity Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Chemistry Biomaterials Bioengineering Biotechnology Polymers and Plastics |
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