NDLI: Ex Vivo and In Vitro Studies on the Cytotoxicity and Immunomodulative Properties of Poly(2-isopropenyl-2-oxazoline) as a New Type of Biomedical Polymer.

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Ex Vivo and In Vitro Studies on the Cytotoxicity and Immunomodulative Properties of Poly(2-isopropenyl-2-oxazoline) as a New Type of Biomedical Polymer.

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Contents: Macromol. Biosci. 8/2016.

Macromol. Biosci. 8/2016.

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Ex Vivo and In Vitro Studies on the Cytotoxicity and Immunomodulative Properties of Poly(2-isopropenyl-2-oxazoline) as a New Type of Biomedical Polymer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kroneková, Zuzana Mikulec, Marcel Petrencíková, Nadezda Paulovicová, Ema Paulovicová, Lucia Jancinová, Viera Nosál', Radomír Reddy, Palem S. Shimoga, Ganesh D. Chorvát, Dusan Kronek, Juraj
Description	Country affiliation: Slovakia Author Affiliation: Kroneková Z ( Department for Biomaterials Research, Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, 845 41, Bratislava, Slovakia.); Mikulec M ( Department for Biomaterials Research, Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, 845 41, Bratislava, Slovakia.); Petrencíková N ( Department for Biomaterials Research, Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, 845 41, Bratislava, Slovakia.); Paulovicová E ( Institute of Chemistry, Center of Glycomics, Slovak Academy of Sciences, Dubravska cesta 9, 84236, Bratislava, Slovakia.); Paulovicová L ( Institute of Chemistry, Center of Glycomics, Slovak Academy of Sciences, Dubravska cesta 9, 84236, Bratislava, Slovakia.); Jancinová V ( Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia.); Nosál' R ( Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia.); Reddy PS ( Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, TrËída T. Bati 5678, Zlin, 760 01, Czech Republic.); Shimoga GD ( Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, TrËída T. Bati 5678, Zlin, 760 01, Czech Republic.); Chorvát D ( International Laser Centre, Ilkovicova 3, 841 04, Bratislava, Slovakia.); Kronek J ( Department for Biomaterials Research, Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, 845 41, Bratislava, Slovakia.)
Abstract	Poly(2-alkenyl-2-oxazoline)s are promising functional polymers for a variety of biomedical applications, such as drug delivery systems, peptide conjugates, or gene delivery. In this study, poly(2-isopropenyl-2-oxazoline) (PIPOx) is prepared through free-radical polymerization initiated with azobisisobutyronitrile. Reactive 2-oxazoline units in the side chain support an addition reaction with different compounds containing a carboxylic group, which facilitates the preparation of polymers labeled with two different fluorescent dyes. The cytotoxicities of 2-oxazoline monomers, PIPOx, and fluorescently labeled PIPOx are evaluated in vitro using an 3-(4,5-Dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and ex vivo using a cell proliferation assay with adenosine triphosphate bioluminescence. The cell uptake of labeled PIPOx is used to determine the colocalization of PIPOx with cell organelles that are part of the endocytic pathway. For the first time, it is shown that poly(2-isopropenyl-2-oxazoline) is a biocompatible material and is suitable for biomedical applications; further, its immunomodulative properties are evaluated.
File Format	HTM / HTML
ISSN	16165187
Issue Number	8
Journal	Macromolecular Bioscience
Volume Number	16
e-ISSN	16165195
Language	English
Publisher	Wiley-VCH
Publisher Date	2016-08-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry
Content Type	Text
Resource Type	Article
Subject	Materials Chemistry Biomaterials Bioengineering Biotechnology Polymers and Plastics

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