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Manic symptoms in youth: dimensions, latent classes, and associations with parental psychopathology.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pan, Pedro Mario Salum, Giovanni Abrahão Gadelha, Ary Moriyama, Tais Cogo-Moreira, Hugo Graeff-Martins, Ana Soledade Rosario, Maria Conceição Polanczyk, Guilherme Vanoni Brietzke, Elisa Rohde, Luis Augusto Stringaris, Argyris Goodman, Robert Leibenluft, Ellen Bressan, Rodrigo Affonseca
Spatial Coverage	Brazil
Description	Author Affiliation: Pan PM ( Federal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil. Electronic address: pedro.pan@unifesp.br.); Salum GA ( INCT-CNPq and Federal University of Rio Grande do Sul, Brazil.); Gadelha A ( Federal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.); Moriyama T ( Federal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.); Cogo-Moreira H ( Federal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.); Graeff-Martins AS ( INCT-CNPq and University of São Paulo, Brazil.); Rosario MC ( Federal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.); Polanczyk GV ( INCT-CNPq and University of São Paulo, Brazil.); Brietzke E ( Federal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.); Rohde LA ( INCT-CNPq and Federal University of Rio Grande do Sul, Brazil.); Stringaris A ( King's College London, UK.); Goodman R ( King's College London, UK.); Leibenluft E ( National Institute of Mental Health (NIMH), USA.); Bressan RA ( Federal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.)
Abstract	OBJECTIVE: The purpose of the study was to define the latent structure of parent-reported manic symptoms and their association with functional impairment and familial risk in a community sample of Brazilian children. METHOD: We screened for manic symptoms in a community sample of 2,512 children 6 to 12 years of age. Parents of children with 'episodes of going abnormally high' completed a detailed mania section (n = 479; 19.1%). Confirmatory factor analysis (CFA) tested a solution with 'Under-Control (UC)' and 'Exuberant (EX)' dimensions, investigating the severity (threshold) and factor loading of each symptom. We also used latent class analysis (LCA) to evaluate the latent categorical structure of manic symptoms. Associations of these latent constructs with psychiatric comorbidity, psychosocial impairment, and family history of psychopathology were tested. RESULTS: The 2-dimensional model fit the data well. Only the UC dimension was associated with psychiatric morbidity, psychosocial impairment, and a family history of mania, depression, or suicide attempts. Both UC and EX items discriminated subjects with 'episodes of going abnormally high,' but EX items lay at the mild end of the severity spectrum, whereas UC items lay at the severe end. The LCA yielded a small group of children with high levels of manic symptoms and a distinct profile of psychiatric comorbidity and impairment ('high-symptom group'). CONCLUSION: In a large, community-based sample, we found a 2-dimensional latent structure for parent-reported manic symptoms in youth, and demonstrated familial associations between the UC dimension and affective disorders. Both UC and EX items are clinically useful, but their contributions vary with symptom severity.
File Format	HTM / HTML
ISSN	08908567
e-ISSN	15275418
DOI	10.1016/j.jaac.2014.03.003
Journal	Journal of the American Academy of Child & Adolescent Psychiatry
Issue Number	6
Volume Number	53
Language	English
Publisher	Elsevier
Publisher Date	2014-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Psychiatry Discipline Pediatrics Bipolar Disorder Epidemiology Mental Disorders Classification Comorbidity Severity Of Illness Index Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Developmental and Educational Psychology Psychiatry and Mental Health

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