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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Golka, Klaus Schmidt, Tobias Seidel, Thilo Dietrich, Holger Roemer, Hermann C. Lohlein, Dietrich Reckwitz, Thomas Sokeland, Jurgen Weistenhofer, Wobbeke Blaszkewicz, Meinolf Selinski, Silvia |
| Description | Country affiliation: Germany Author Affiliation: Golka K ( Leibniz Research Centre for Working Environment and Human Factors, Institut fur Arbeitsphysiologie an der Universitat Dortmund (IfADo), Dortmund, Germany.) |
| Abstract | Cigarette smoking is the most important risk factor for development of transitional cell carcinoma of the urinary bladder. The effect of polymorphisms of glutathione S-transferases M1 (GSTM1) and M3 (GSTM3) on the influence of cigarette smoking on urinary bladder carcinogenesis was investigated. In total, 293 bladder cancer patients from hospitals in Dortmund and Wittenberg as well as 176 patients without any malignancy from a Department of Surgery from Dortmund were genotyped for GSTM1 and GSTM3 according to standard PCR/RFLP methods. Smoking habits were quantified by a standardized interview. The proportion of GSTM1 negative cases was 63% in the entire bladder cancer cases group compared to 50% in controls. The GSTM3*A/*A genotype was 76% in cancer cases versus 74% in controls. Smokers and ex-smokers were overrepresented in bladder cancer cases. A significant association between smoking status and GSTM1 or GSTM3 genotype was not detected. The elevated proportion of GSTM1 negative bladder cancer cases shows an effect of this polymorphic enzyme on development of bladder cancer. In contrast to other studies, an influence of GSTM1 on the risk due to cigarette smoking was not observed. |
| File Format | HTM / HTML |
| ISSN | 15287394 |
| Issue Number | 13-14 |
| Volume Number | 71 |
| e-ISSN | 10872620 |
| Journal | Journal of Toxicology and Environmental Health, Part A |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2008-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Toxicology Carcinoma, Transitional Cell Enzymology Glutathione Transferase Genetics Polymorphism, Genetic Urinary Bladder Neoplasms Aged Chemically Induced Case-control Studies Female Gene Expression Regulation, Enzymologic Genetic Predisposition To Disease Genotype Metabolism Humans Male Middle Aged Odds Ratio Risk Factors Smoking Adverse Effects Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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