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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lang, Iain A. Scarlett, Alan Guralnik, Jack M. Depledge, Michael H. Melzer, David Galloway, Tamara S. |
| Description | Country affiliation: United kingdom Author Affiliation: Lang IA ( Epidemiology and Public Health Group, Peninsula Medical School, Exeter, United Kingdom.) |
| Abstract | Exposure to heavy metals promotes oxidative stress and damage to cellular components, and may accelerate age-related disease and disability. Physical mobility is a validated biomarker of age-related disability and is predictive of hospitalization and mortality. Our study examined associations between selected heavy metals and impaired lower limb mobility in a representative older human population. Data for 1615 adults aged >or=60 yr from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2004 were used to identify associations between urinary concentrations of 10 metals with self-reported and measured significant walking impairments. Models were adjusted for confounding factors, including smoking. In models adjusted for age, gender, and ethnicity, elevated levels of cadmium, cobalt, and uranium were associated with impairment of the ability to walk a quarter mile. In fully adjusted models, cobalt was the only metal that remained associated: the odds ratio (OR) for reporting walking problems with a 1-unit increase in logged cobalt concentration (mug/L) was 1.43 (95% CI 1.12 to 1.84). Cobalt was also the only metal associated with a significant increased measured time to walk a 20-ft course. In analyses of disease categories to explain the mobility finding, cobalt was associated with physician diagnosed arthritis (1-unit increase OR = 1.22 (95% CI 1.00 to 1.49). Low-level cobalt exposure, assessed through urinary concentrations of this essential heavy metal, may be a risk factor for age-related physical impairments. Independent replication is needed to confirm this association. |
| File Format | HTM / HTML |
| ISSN | 15287394 |
| e-ISSN | 10872620 |
| DOI | 10.1080/15287390802647336 |
| Journal | Journal of Toxicology and Environmental Health, Part A |
| Issue Number | 6 |
| Volume Number | 72 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2009-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Environmental Health Discipline Toxicology Cobalt Adverse Effects Mobility Limitation Nutrition Surveys Walking Activities Of Daily Living Cadmium Urine Cross-sectional Studies Disability Evaluation Logistic Models Odds Ratio Risk Factors Sensitivity And Specificity Uranium Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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