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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gluhcheva, Yordanka Atanasov, Vasil Ivanova, Juliana Mitewa, Mariana |
| Description | Country affiliation: Bulgaria Author Affiliation: Gluhcheva Y ( Institute of Experimental Morphology, Pathology, and Anthropology With Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria. ygluhcheva@hotmail.com) |
| Abstract | Cobalt(II) accumulates in organs such as spleen, kidneys, heart, and liver. The aim of the present study was to investigate the effects of cobalt ethylenediamine tetraacetic acid (Co-EDTA) on spleen of developing mice. Pregnant BALB/c mice in late gestation were subjected to Co-EDTA treatment at daily doses of 75 or 125 mg/kg in drinking water, which continued until d 90 of the newborn pups. The newborn pups were sacrificed on d 18, 25, 30, 45, 60, and 90, which correspond to different stages of development. Spleens were excised, weighed, and processed for histological analysis. Spleen index (SI) was calculated as a ratio of spleen weight to body weight. Cobalt(II) bioaccumulation in spleen was determined using flame atomic absorption spectrometry (FAAS). Preliminary results showed that chronic treatment of mice with low- or high-dose Co-EDTA disturbed extramedullary hematopoiesis in the spleen. The number of megakaryocytes was reduced compared to controls. SI was also reduced in d 18 mice treated with low- or high-dose Co-EDTA. However, exposure to 75 mg/kg led to an increase of SI in all other experimental groups. FAAS analysis revealed significant cobalt(II) accumulation in spleen of treated mice. The Co(II) levels in spleens of d 18 mice were highest compared to other experimental groups, indicating that at this period mice are more sensitive to treatment. Exposure to cobalt-EDTA resulted in accumulation of Co(II) in spleen, altered SI, and hematopoiesis. Immature mice appear to be more sensitive to chronic treatment than adults. |
| File Format | HTM / HTML |
| ISSN | 15287394 |
| Issue Number | 22-23 |
| Volume Number | 75 |
| e-ISSN | 10872620 |
| Journal | Journal of Toxicology and Environmental Health, Part A |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Toxicology Cobalt Toxicity Environmental Pollutants Spleen Drug Effects Animals Cell Count Administration & Dosage Pharmacokinetics Dose-response Relationship, Drug Edetic Acid Female Hematopoiesis, Extramedullary Lactation Male Maternal Exposure Adverse Effects Megakaryocytes Pathology Mice Mice, Inbred Balb C Organ Size Pregnancy Prenatal Exposure Delayed Effects Chemistry Growth & Development Tissue Distribution Toxicity Tests, Chronic Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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