NDLI: Cytogenetic and immunological effects associated with occupational formaldehyde exposure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Costa, Solange García-Lestón, Julia Coelho, Marta Coelho, Patrícia Costa, Carla Silva, Susana Porto, Beatriz Laffon, Blanca Teixeira, João Paulo
Spatial Coverage	Portugal
Description	Country affiliation: Portugal Author Affiliation: Costa S ( National Institute of Health , Environmental Health Department, Porto, Portugal. solange.costa2@gmail.com)
Abstract	Formaldehyde (FA) is a widely used industrial chemical for which exposure is associated with nasopharyngeal and sinonasal cancer. Based on sufficient evidence of carcinogenicity from human investigations, supporting studies on mechanisms underlying carcinogenesis, and experimental evidence in animals, FA status was recently revised and reclassified as a human carcinogen. The highest level of exposure to FA occurs in occupational settings. Although several studies reported FA ability to induce genotoxic responses in exposed workers, not all findings were conclusive. In addition, published studies on the immunological effects of FA indicate that this compound may be able to modulate immune responses, although data in exposed subjects are still preliminary. In this study a group of pathology anatomy workers exposed to FA was evaluated for cytogenetic and immunological parameters. A control group with similar sociodemographic characteristics and without known occupational exposure to FA was also included. Genotoxicity was evaluated by means of micronucleus (MN) test, sister chromatid exchanges (SCE), and T-cell receptor (TCR) mutation assay. Percentages of different lymphocyte subpopulations were selected as immunotoxic biomarkers. The mean level of FA environmental exposure was 0.36 ± 0.03 ppm. MN and SCE frequencies were significantly increased in the exposed group. A significant decrease of the percentage of B cells in the exposed group was also found. Data obtained in this study indicate that genotoxic and immunotoxic increased risk due to FA occupational exposure cannot be excluded. Implementation of effective control measures along with hazard prevention campaigns may be crucial to decrease the risk.
File Format	HTM / HTML
ISSN	15287394
Issue Number	4-5
Volume Number	76
e-ISSN	10872620
Journal	Journal of Toxicology and Environmental Health, Part A
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Toxicology Air Pollutants, Occupational Toxicity Fixatives Formaldehyde Occupational Exposure Pathology Department, Hospital Adult Analysis Azure Stains Environmental Monitoring Female Flow Cytometry Humans Lymphocytes Drug Effects Male Micronucleus Tests Microscopy, Fluorescence Middle Aged Mutation Portugal Receptors, Antigen, T-cell Metabolism Sister Chromatid Exchange Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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