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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zong, Yunfeng Gao, Junlan Feng, Huiyun Cheng, Beijiu Zhang, Xin |
| Description | Author Affiliation: Zong Y ( a School of Life Sciences , Anhui Agricultural University , Hefei , P. R. China.) |
| Abstract | 7-Ketocholesterol is one of the most abundant cholesterol oxides, and is known to be cytotoxic to various types of cultured mammalian cells; however, little is known regarding its effects in vivo. With the use of the nematode Caenorhabditis elegans as model organism, in vivo toxicity of 7-ketocholesterol was investigated. The aim of the study was to examine the effects on life span, as well as short-term effects on reproduction, thermotolerance, germline apoptosis, and reactive oxygen species (ROS) generation resulting from C. elegans exposure to 7-ketocholesterol at concentrations ranging from 0 to 200 µg/ml. Results indicated that 7-ketocholesterol reduced reproductive capacity, shortened the life span in a concentration-dependent manner, and impaired thermotolerance of the adult nematode. 7-Ketocholesterol also induced germline apoptotic cell death and increased ROS generation in adult worms. Thus, the model organism C. elegans is recommended for assessment of the safety and bioactivity of cholesterol oxides. |
| File Format | HTM / HTML |
| ISSN | 15287394 |
| Issue Number | 12 |
| Volume Number | 77 |
| e-ISSN | 10872620 |
| Journal | Journal of Toxicology and Environmental Health, Part A |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2014-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Toxicology Apoptosis Drug Effects Caenorhabditis Elegans Ketocholesterols Toxicity Animals Cytology Growth & Development Longevity Reactive Oxygen Species Metabolism Reproduction Toxicity Tests, Acute Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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