NDLI: Exploring the frontiers of synthetic eumelanin polymers by high-resolution matrix-assisted laser/desorption ionization mass spectrometry.

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Exploring the frontiers of synthetic eumelanin polymers by high-resolution matrix-assisted laser/desorption ionization mass spectrometry.

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Exploring the frontiers of synthetic eumelanin polymers by high-resolution matrix-assisted laser/desorption ionization mass spectrometry.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reale, Samantha Crucianelli, Marcello Pezzella, Alessandro D'ischia, Marco De Angelis, Francesco
Description	Country affiliation: Italy Author Affiliation: Reale S ( Department of Chemistry, Chemical Engineering and Materials, University of L'Aquila, Via Vetoio, I-67100, Coppito, L'Aquila, Italy.)
Abstract	New trends in material science and nanotechnologies have spurred growing interest in eumelanins black insoluble biopolymers derived by tyrosinase-catalysed oxidation of tyrosine via 5,6-dihydroxyindole (DHI) and its 2-carboxylic acid (DHICA). Efficient antioxidant and photoprotective actions, associated with peculiar optoelectronic properties, are recognised as prominent functions of eumelanin macromolecules within the human and mammalian pigmentary system, making them unique candidates for the realisation of innovative bio-inspired functional soft materials, with structure-based physical-chemical properties. An unprecedented breakthrough into the mechanism of synthetic eumelanin buildup has derived from a detailed investigation of the oxidative polymerization of DHI and its N-methyl derivative (NMDHI) by linear and reflectron matrix-assisted laser/desorption ionization mass spectrometry. Regular collections of oligomers of increasing masses, spanning the entire m/z ranges up to 5000 Da (>30-mer) and 8000 Da (> 50-mer) for the two building blocks, respectively, were disclosed. It is the first time that the in vitro polymerisation of dihydroxyindoles to form synthetic eumelanins is explored up to its high mass limits, giving at the same time information on the polymerisation mode, whether it follows a stepwise pattern (being this the conclusion in our case) or a staking sequencing of small-sized entities. It also highlighted the influence of the N-methyl substituent on the polymerization process; this opens the way to the production of N-functionalized, synthetic eumelanin-inspired soft materials, for possible future technological applications.
File Format	HTM / HTML
ISSN	10765174
Issue Number	1
Volume Number	47
e-ISSN	10969888
Journal	Journal of Mass Spectrometry
Language	English
Publisher	Wiley
Publisher Date	2012-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Spectroscopy Discipline Chemistry Techniques Biopolymers Chemistry Indoles Melanins Spectrometry, Mass, Matrix-assisted Laser Desorption-ionization Methods Oxidation-reduction Polymerization Tyrosine Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Medicine

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