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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Raju, B. Ramesh, M. Borkar, Roshan M. Padiya, Raju Banerjee, Sanjay K. Srinivas, R. |
| Description | Country affiliation: India Author Affiliation: Raju B ( National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad, 500 007, India.) |
| Abstract | In vivo metabolites of ketorolac (KTC) have been identified and characterized by using liquid chromatography positive ion electrospray ionization high resolution tandem mass spectrometry (LC/ESI-HR-MS/MS) in combination with online hydrogen/deuterium exchange (HDX) experiments. To identify in vivo metabolites, blood urine and feces samples were collected after oral administration of KTC to Sprague-Dawley rats. The samples were prepared using an optimized sample preparation approach involving protein precipitation and freeze liquid separation followed by solid-phase extraction and then subjected to LC/HR-MS/MS analysis. A total of 12 metabolites have been identified in urine samples including hydroxy and glucuronide metabolites, which are also observed in plasma samples. In feces, only O-sulfate metabolite and unchanged KTC are observed. The structures of metabolites were elucidated using LC-MS/MS and MS(n) experiments combined with accurate mass measurements. Online HDX experiments have been used to support the structural characterization of drug metabolites. The main phase I metabolites of KTC are hydroxylated and decarbonylated metabolites, which undergo subsequent phase II glucuronidation pathways. |
| File Format | HTM / HTML |
| ISSN | 10765174 |
| Issue Number | 7 |
| Volume Number | 47 |
| e-ISSN | 10969888 |
| Journal | Journal of Mass Spectrometry |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Spectroscopy Discipline Chemistry Techniques Chromatography, Liquid Methods Ketorolac Chemistry Metabolism Spectrometry, Mass, Electrospray Ionization Animals Deuterium Exchange Measurement Feces Analysis Pharmacokinetics Male Models, Molecular Rats Rats, Sprague-dawley Tandem Mass Spectrometry Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Medicine |
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