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Identification of an adult stem/progenitor cell-like population in the human thyroid.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fierabracci, Alessandra Puglisi, Maria Ausiliatrice Giuliani, Laura Mattarocci, Stefano Gallinella-Muzi, Marco
Description	Country affiliation: Italy Author Affiliation: Fierabracci A ( Autoimmunity and Organ Regeneration Laboratory, Ospedale Pediatrico Bambino Gesù Scientific Institute, Children's Hospital Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. fierabracci@med.uniroma2.it)
Abstract	There is evidence that tissue-specific stem cells reside in certain adult tissues. Their specific properties remain elusive, because they are rare and heterogeneous in parent tissues; furthermore, technical difficulties have been encountered in the identification and characterization of their progeny. The aim of this study was to isolate stem/progenitor cells from the human thyroid. We devised a method based on the enzymatic digestion of fresh surgical thyroid specimens, followed by culture of cells in the presence of epidermal growth factor and basic fibroblast growth factor. We also used markers that identify and characterize these cells. Spheroids with self-replicative potential were obtained from all thyroid specimens. The isolated population contained a subset of CD34+ CD45- cells and it was able, in differentiation conditions, to generate follicles with thyroid hormonal production. In support of the plasticity concept, we obtained evidence that, when most freshly isolated spheroids were co-cultured with a neuroblastoma cell line, they produced progeny expressing the neuronal marker beta-tubulin III. Spheroids were also able to undergo adipogenic differentiation when cultured in adipogenic medium. We conclude that a predominant functional type of stem/progenitor cell exists within the thyroid, with an intrinsic ability to generate thyroidal cells and the potential to produce non-thyroidal cells.
File Format	HTM / HTML
ISSN	00220795
e-ISSN	14796805
Journal	Journal of Endocrinology
Issue Number	3
Volume Number	198
Language	English
Publisher	BioScientifica
Publisher Date	2008-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Endocrinology Spheroids, Cellular Cytology Stem Cells Thyroid Gland Antigens, Cd34 Immunology Antigens, Cd45 Cell Culture Techniques Cell Differentiation Drug Effects Cell Line, Tumor Cell Proliferation Cells, Cultured Coculture Techniques Epidermal Growth Factor Pharmacology Fibroblast Growth Factor 2 Flow Cytometry Immunohistochemistry Immunophenotyping Reverse Transcriptase Polymerase Chain Reaction Metabolism Telomerase Telomere Genetics Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology

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