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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chatzigeorgiou, Antonios Kandaraki, Eleni Piperi, Christina Livadas, Sarantis Papavassiliou, Athanasios G. Koutsilieris, Michael Papalois, Apostolos Diamanti-Kandarakis, Evanthia |
| Description | Country affiliation: Greece Author Affiliation: Chatzigeorgiou A ( Department of Experimental Physiology, University of Athens Medical School, Athens, Greece. e.diamanti.kandarakis@gmail.com) |
| Abstract | The levels of advanced glycation end products (AGEs) are increased under conditions of impaired glucose metabolism and/or oxidative stress, promoting insulin resistance and other endocrine abnormalities. AGEs play a major role in the pathogenesis of several diseases such as diabetes, atherosclerosis, polycystic ovary syndrome and Alzheimer's disease, contributing to progressive ageing. Receptor-based clearance of AGEs by the receptor for AGE (RAGE) and/or the macrophage scavenger receptor A (SR-A) is considered as a main factor for the regulation of the concentration of AGEs under these conditions. This study aimed to investigate the expression of RAGE (AGER) and SR-A (MSR1) under high/low-dietary AGE conditions in vivo and their potential contribution to the metabolic and sex hormonal profile of female rats. Female Wistar rats were fed a low-AGE or high-AGE diet for 3 months. Serum samples were collected at baseline and at the completion of the 3-month period for the measurements of metabolic and hormonal parameters. Peripheral blood mononuclear cells (PBMCs) were isolated for the determination of the expression of RAGE and SR-A. The high-AGE diet-fed rats exhibited increased glucose, insulin and testosterone levels as well as decreased oestradiol and progesterone levels compared with the low-AGE diet-fed ones, thus indicating a metabolic and hormonal dysregulation attributed to high-AGE dietary exposure. The expression of RAGE was significantly down-regulated in the PBMCs of the high-AGE diet-fed rats (P=0.041), and it was correlated negatively with insulin and testosterone levels and positively with progesterone levels. The expression of SR-A was also decreased in the high-AGE diet-fed rats to marginal significance. Decreased monocytic expression of scavenger receptors such as RAGE and SR-A may result in a higher deposition of AGEs in peripheral endocrine tissues, thus promoting endocrine-related abnormalities and diseases. |
| File Format | HTM / HTML |
| ISSN | 00220795 |
| e-ISSN | 14796805 |
| Journal | Journal of Endocrinology |
| Issue Number | 3 |
| Volume Number | 218 |
| Language | English |
| Publisher | BioScientifica |
| Publisher Date | 2013-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Endocrinology Diet Adverse Effects Estradiol Blood Glycosylation End Products, Advanced Metabolism Insulin Progesterone Receptors, Immunologic Receptors, Scavenger Testosterone Advanced Glycosylation End Product-specific Receptor Animals Glucose Toxicity Leukocytes, Mononuclear Rats, Wistar Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology |
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