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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Balsevich, Georgia Uribe, Andres Wagner, Klaus V. Hartmann, Jakob Santarelli, Sara Labermaier, Christiana Schmidt, Mathias V. |
| Description | Country affiliation: Germany Author Affiliation: Balsevich G ( Max Planck Institute of PsychiatryKraepelinstr. 2-10, 80804 Munich, Germany georgia_balsevich@mpipsykl.mpg.de.); Uribe A ( Max Planck Institute of PsychiatryKraepelinstr. 2-10, 80804 Munich, Germany.); Wagner KV ( Max Planck Institute of PsychiatryKraepelinstr. 2-10, 80804 Munich, Germany.); Hartmann J ( Max Planck Institute of PsychiatryKraepelinstr. 2-10, 80804 Munich, Germany.); Santarelli S ( Max Planck Institute of PsychiatryKraepelinstr. 2-10, 80804 Munich, Germany.); Labermaier C ( Max Planck Institute of PsychiatryKraepelinstr. 2-10, 80804 Munich, Germany.); Schmidt MV ( Max Planck Institute of PsychiatryKraepelinstr. 2-10, 80804 Munich, Germany.) |
| Abstract | While it is known that stress promotes obesity, the effects of stress within an obesogenic context are not so clear and molecular targets at the interface remain elusive. The FK506-binding protein 51 (FKBP51, gene: Fkbp5) has been identified as a target gene implicated in the development of stress-related psychiatric disorders and is a possible candidate for involvement in stress and metabolic regulation. The aims of the current study are to investigate the interaction between chronic stress and an obesogenic context and to additionally examine whether FKBP51 is involved in this interaction. For this purpose, male C57BL/6 mice were exposed to a high-fat diet for 8 weeks before being challenged with chronic social defeat stress. Herein, we demonstrate that chronic stress induces hypophagia and weight loss, ultimately improving features arising from an obesogenic context, including glucose tolerance and levels of insulin and leptin. We show that Fkbp5 expression is responsive to diet and stress in the hypothalamus and hippocampus respectively. Furthermore, under basal conditions, higher levels of hypothalamic Fkbp5 expression were related to increased body weight gain. Our data indicate that Fkbp5 may represent a novel target in metabolic regulation. |
| File Format | HTM / HTML |
| ISSN | 00220795 |
| e-ISSN | 14796805 |
| Journal | Journal of Endocrinology |
| Issue Number | 1 |
| Volume Number | 222 |
| Language | English |
| Publisher | BioScientifica |
| Publisher Date | 2014-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Endocrinology Diet, High-fat Adverse Effects Obesity Etiology Physiopathology Stress, Psychological Tacrolimus Binding Proteins Physiology Animals Corticosterone Blood Disease Models, Animal Energy Metabolism Glucose Metabolism Hippocampus Hypothalamus Mice Mice, Inbred C57bl Weight Gain Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology |
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