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Cardiac regulation and electrocardiographic factors contributing to the measurement of repolarization variability.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Couderc, Jean-Philippe
Description	Country affiliation: United States Author Affiliation: Couderc JP ( Heart Research follow-up Program, Department of Cardiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA. heartjpc@heart.rochester.edu)
Abstract	Cellular and macroelectrical instability within the heart ventricles during repolarization is described as a potential triggering mechanism of life-threatening arrhythmias. Although this phenomenon was observed in animal and in vitro studies, significant efforts have been put into the design of computerized technologies to quantify very subtle variations of the repolarization signal from the surface electrocardiograms. These technologies aim at capturing repolarization instability of ventricular repolarization while controlling for the normal variability. Currently, the methods have focused on the autonomic regulation of the heart rate as a primary confounding factor (such as in the QT variability index). However, there are other factors that can influence the measurements of beat-to beat variability of the repolarization segment. Among them, the amplitude of the repolarization signal, the selected lead, and the heart vector orientation are very important and too often neglected in clinical investigations. We will discuss these factors and provocatively describe why they should be cautiously considered to avoid erroneous measurements of repolarization instability.
File Format	HTM / HTML
ISSN	00220736
Issue Number	6
Volume Number	42
e-ISSN	15328430
Journal	Journal of Electrocardiology
Language	English
Publisher	Elsevier
Publisher Date	2009-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cardiology Artifacts Electrocardiography Instrumentation Methods Heart Conduction System Physiopathology Heart Rate Models, Cardiovascular Reproducibility Of Results Sensitivity And Specificity Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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