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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Arteyeva, Natalia V. Goshka, Sergey L. Sedova, Ksenia A. Bernikova, Olesya G. Azarov, Jan E. |
| Description | Country affiliation: RUSSIA Author Affiliation: Arteyeva NV ( Laboratory of Cardiac Physiology, Institute of Physiology, Komi Science Center, Ural Branch, Russian Academy of Sciences, 50, Pervomayskaya st, Syktyvkar, Russia.) |
| Abstract | BACKGROUND: It is unclear whether the Tpeak-Tend interval is an index of the transmural or the total dispersion of repolarization. METHODS: We examined the Tpeak-Tend interval using a computer model of the rabbit heart ventricles based on experimentally measured transmural, apicobasal, and interventricular gradients of action potential duration. RESULTS: Experimentally measured activation-recovery intervals increased from apex to base, from the left ventricle to the right ventricle, and in the apical portion of the left ventricle from epicardium to endocardium and from the right side of septum to the left side. The simulated Tpeak corresponded to the earliest end of repolarization, whereas the Tend corresponded to the latest end of repolarization. The different components of the global repolarization dispersion were discerned by simulation. CONCLUSIONS: The Tpeak-Tend interval corresponds to the global dispersion of repolarization with distinct contributions of the apicobasal and transmural action potential duration gradients and apicobasal difference in activation times. |
| File Format | HTM / HTML |
| ISSN | 00220736 |
| Issue Number | 4 |
| Volume Number | 46 |
| e-ISSN | 15328430 |
| Journal | Journal of Electrocardiology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cardiology Action Potentials Physiology Electrocardiography Methods Heart Conduction System Models, Cardiovascular Ventricular Function, Right Animals Computer Simulation Rabbits Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
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