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Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Talabot-Ayer, Dominique McKee, Thomas Gindre, Patrizia Bas, Sylvette Baeten, Dominique L. Gabay, Cem Palmer, Gaby
Description	Country affiliation: Switzerland Author Affiliation: Talabot-Ayer D ( Division of Rheumatology, University Hospital, Geneva, Switzerland.)
Abstract	OBJECTIVES: Recent evidence suggests a role for interleukin (IL)-33 and its receptor ST2 in arthritis. In this study, we quantified IL-33 and soluble (s)ST2 levels in serum and synovial fluid (SF), and assessed synovial IL-33 expression levels and pattern in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), or osteoarthritis (OA). METHODS: Serum and SF IL-33 and sST2 levels were assessed by ELISA. IL-33 mRNA was quantified by RT-qPCR. Synovial IL-33 protein expression pattern was examined by immunohistochemistry. RESULTS: Serum and SF IL-33 levels tended to be higher in RA than in OA patients. In contrast to RA, IL-33 was not detectable in PsA serum and SF. Serum sST2 levels were higher in RA than in OA. There was a wide variation of synovial tissue IL-33 mRNA expression within each disease group and IL-33 mRNA levels were not significantly different between the groups. A similar IL-33 protein expression pattern was observed in RA, PsA and OA synovium, with strong nuclear expression of IL-33 in endothelial cells and, in a subset of RA, PsA and OA patients, in cells morphologically consistent with synovial fibroblasts. DISCUSSION/CONCLUSIONS: This study confirms increased circulating IL-33 levels in RA. In addition, we report that IL-33 is undetectable in the serum or SF of PsA patients. Local expression of IL-33 in the synovium was observed at similar variable levels in RA, PsA and OA, suggesting that inflamed joints do not represent the primary source of elevated serum and SF levels of IL-33 in RA.
File Format	HTM / HTML
ISSN	1297319X
Issue Number	1
Volume Number	79
e-ISSN	17787254
Journal	Joint Bone Spine
Language	English
Publisher	Elsevier
Publisher Date	2012-01-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Rheumatology Arthritis, Psoriatic Metabolism Arthritis, Rheumatoid Interleukins Osteoarthritis Synovial Fluid Adult Aged Aged, 80 And Over Diagnosis Genetics Biological Markers Female Gene Expression Humans Interleukin-33 Male Middle Aged Rna, Messenger Analysis Synovial Membrane Chemistry Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Rheumatology

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