NDLI: Regulation of mTOR Pathway in Exercise-induced Cardiac Hypertrophy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liao, J. Li, Y. Zeng, F. Wu, Y.
Description	Country affiliation: China Author Affiliation: Liao J ( Department of Sport Science, Beijing Sport University, Beijing, China.); Li Y ( Department of Sport, Jianghan University, Wuhan, China.); Zeng F ( Department of Sport Science, Beijing Sport University, Beijing, China.); Wu Y ( Department of Sport Science, Beijing Sport University, Beijing, China.)
Abstract	This study was designed to examine whether the mTOR signaling pathway would respond to long-term different intensity exercises and to observe the impact of exercise upon possible cardiac damage. Male Sprague Dawley rats were randomly divided into control group, moderate-intensity exercise group and high-intensity exercise group, and each exercise group had 4 observation time points (1-24 h). Exercise training lasted 8 weeks with a 2-day break for each week. Serum cTnI was measured by ELSIA and myocardium histology was assessed by HE and HBFP. The expressions of Akt, mTOR, p70(S6K) and their phosphorylated forms were determined by western-blot. Both exercises were effective at inducing cardiac hypertrophy, wherein magnitude increased with exercise intensity. The significantly high level of serum cTnI in the high-intensity group was accompanied by obvious myocellular abnormalities and ischemia in the myocardium. Significant activation of Akt, mTOR and p70(S6K) were observed in the moderate exercise group but not in the high-intensity exercise group. Results indicate that long-term high-intensity exercise training would induce cardiac hypertrophy accompanied by damage to the heart, entailing a risk of pathological changes. There might be a pivotal regulatory role of the mTOR signaling pathway on cardiac hypertrophy after long-term moderate exercise, but not after high-intensity exercise.
File Format	HTM / HTML
ISSN	01724622
Issue Number	5
Volume Number	36
e-ISSN	14393964
Journal	International Journal of Sports Medicine
Language	English
Publisher	Thieme
Publisher Date	2015-05-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Sports Medicine Cardiomegaly Physiopathology Heart Anatomy & Histology Myocardium Metabolism Physical Conditioning, Animal Physiology Tor Serine-threonine Kinases Animals Body Mass Index Male Models, Animal Rats Rats, Sprague-dawley Risk Factors Signal Transduction Troponin I Blood Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science

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