NDLI: The Effects of Chronic Nitrate Supplementation and the Use of Strong and Weak Antibacterial Agents on Plasma Nitrite Concentration and Exercise Blood Pressure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McDonagh, S. T. J. Wylie, L. J. Winyard, P. G. Vanhatalo, A. Jones, A. M.
Description	Country affiliation: United kingdom Author Affiliation: McDonagh ST ( Sport and Health Sciences, University of Exeter, Exeter, United Kingdom.); Wylie LJ ( Sport and Health Sciences, University of Exeter, Exeter, United Kingdom.); Winyard PG ( University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.); Vanhatalo A ( Sport and Health Sciences, University of Exeter, Exeter, United Kingdom.); Jones AM ( Sport and Health Sciences, University of Exeter, Exeter, United Kingdom.)
Abstract	Chlorhexidine-containing mouthwash (STRONG), which disturbs oral microflora, has been shown to diminish the rise in plasma nitrite concentration ([NO2-]) and attenuate the reduction in resting blood pressure (BP) typically seen after acute nitrate (NO3-) ingestion. We aimed to determine whether STRONG and weaker antiseptic agents attenuate the physiological effects of chronic NO3- supplementation using beetroot juice (BR). 12 healthy volunteers mouth-rinsed with STRONG, non-chlorhexidine mouthwash (WEAK) and deionised water (CON) 3 times a day, and ingested 70 mL BR (6.2 mmol NO3-), twice a day, for 6 days. BP (at rest and during 10 min of treadmill walking) and plasma and salivary [NO3-] and [NO2-] were measured prior to and on day 6 of supplementation. The change in salivary [NO3-] 4 h post final ingestion was higher (P<0.05) in STRONG (8.7±3.0 mM) compared to CON (6.3±0.9 mM) and WEAK (6.0±3.0 mM). In addition, the rise in plasma [NO2-] at 2 h was lower in STRONG compared with WEAK (by 89±112 nM) and CON (by 200±174 nM) and in WEAK compared with CON (all P<0.05). Changes in resting BP were not different between conditions (P>0.05). However, during treadmill walking, the increase in systolic and mean arterial BP was higher 4 h after the final nitrate bolus in STRONG compared with CON (P<0.05) but not WEAK. The results indicate that both strong and weak antibacterial agents suppress the rise in plasma [NO2-] observed following the consumption of a high NO3- diet and the former can influence the BP response during low-intensity exercise.
File Format	HTM / HTML
ISSN	01724622
Issue Number	14
Volume Number	36
e-ISSN	14393964
Journal	International Journal of Sports Medicine
Language	English
Publisher	Thieme
Publisher Date	2015-12-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Sports Medicine Anti-bacterial Agents Pharmacology Blood Pressure Drug Effects Chlorhexidine Dietary Supplements Exercise Physiology Nitrates Nitrites Blood Administration & Dosage Beta Vulgaris Cross-over Studies Double-blind Method Female Fruit And Vegetable Juices Heart Rate Humans Male Mouthwashes Analysis Pulse Wave Analysis Saliva Chemistry Vascular Stiffness Young Adult Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science

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