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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Stachowska, Ewa Siennicka, Aldona Baskiewcz-Halasa, Magdalena Bober, Joanna Machalinski, Boguslaw Chlubek, Dariusz |
| Description | Country affiliation: Poland Author Affiliation: Stachowska E ( Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin, Poland. ewast@sci.pam.szczecin.pl) |
| Abstract | Dysfunction of endothelial cells and activation of monocytes in the vascular wall are important pathogenetic factors of atherosclerosis. Conjugated linoleic acids (CLAs) can modulate the function of immune system in humans: reduce the concentration of atherogenic lipoproteins, and the intensity of inflammatory processes in the plasma. In this paper, we focus on macrophage's surface integrins (ß1 integrin CD49d/CD29-(VLA4); Mac-1 as well as endothelial human vein endothelial cell (HUVEC) surface adhesins: vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion molecule-1 (ICAM-1)) expression in relation to CLA isomer used during cell culture. Both CLA isomers decreased expression of VLA-4 and Mac-1 on macrophages compared with control cells (cultured with bovine serum albumine (BSA) or oxidized form of low-density lipoproteins). cis-9, trans-11 CLA isomer reduced ICAM-1 and VCAM-1 expression on the endothelium surface. Strong tendency to reduce of adhesion of macrophages to HUVEC in the cells cultured with CLA isomers was observed. The potential role of cis-9, trans-11 CLA in the reduction of adhesion of macrophages to the HUVEC--one of the important steps in the inflammatory process, can be considerate. These mechanisms may contribute to the potent anti-atherosclerotic effects of CLA in vivo. |
| File Format | HTM / HTML |
| ISSN | 09637486 |
| Issue Number | 1 |
| Volume Number | 63 |
| e-ISSN | 14653478 |
| Journal | International Journal of Food Sciences and Nutrition |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Sciences Endothelium, Vascular Drug Effects Integrin Alpha4beta1 Metabolism Intercellular Adhesion Molecule-1 Linoleic Acids, Conjugated Pharmacology Macrophage-1 Antigen Macrophages Vascular Cell Adhesion Molecule-1 Animals Atherosclerosis Prevention & Control Cattle Cell Adhesion Cell Culture Techniques Dietary Fats Therapeutic Use Endothelial Cells Cytology Humans Inflammation Isomerism Linoleic Acid Chemistry Lipoproteins, Ldl Serum Albumin Umbilical Veins Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Food Science |
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