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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mizote, A. Okazaki, Y. Iqbal, M. Okada, S. |
| Description | Country affiliation: Japan Author Affiliation: Mizote A ( Faculty of Medicine, Department of Pathological Research, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.) |
| Abstract | We have evaluated the effect of dietary antioxidant, antioxidant biofactor (a processed grain food), on iron nitrilotriacetate-induced renal tumorigenesis, hyperproliferative response, and oxidative damage. In tumorigenesis studies, iron nitrilotriacetate alone treatment resulted in a development of 75% renal cell tumor incidence, whereas, in the group of animals fed with antioxidant biofactor diet and treated with iron nitrilotriacetate, only 43% of renal cell tumor incidence was observed. In oxidative damage studies, the decrease in the level of renal glutathione and antioxidant enzymes induced by iron nitrilotriacetate was significantly reversed by antioxidant biofactor diet pretreatment in a dose-dependent manner (18-71% recovery, P < 0.05). Antioxidant biofactor diet pretreatment also resulted in a dose-dependent inhibition (35-49% inhibition, P < 0.05) of iron nitrilotriacetate-induced lipid peroxidation as measured by thiobarbituric acid reactive substances formation in renal tissues. Similarly, in hyperproliferation studies, antioxidant biofactor diet pretreatment showed a strong inhibition of iron nitrilotriacetate-induced renal ornithine decarboxylase activity (18-54% inhibition, P < 0.05). In addition, antioxidant biofactor fed diet pretreatment also protected the kidney tissues against observed histopathological alterations. From this data, it can be concluded that antioxidant biofactor diet can abrogate the toxic and tumor promoting effects of iron nitrilotriacetate and can serve as a potent chemopreventive agent to suppress oxidant-induced tissue injury and tumorigenesis. |
| File Format | HTM / HTML |
| ISSN | 09603271 |
| Issue Number | 3 |
| Volume Number | 27 |
| e-ISSN | 14770903 |
| Journal | Human & Experimental Toxicology |
| Language | English |
| Publisher | Sage Publication |
| Publisher Date | 2008-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Toxicology Ferric Compounds Toxicity Kidney Neoplasms Prevention & Control Nitrilotriacetic Acid Analogs & Derivatives Phenols Pharmacology Plant Extracts Animals Cell Proliferation Drug Effects Dose-response Relationship, Drug Glutathione Metabolism Chemically Induced Lipid Peroxidation Male Ornithine Decarboxylase Inhibitors Oxidation-reduction Rats Rats, Wistar Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology |
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