NDLI: Effect of zinc in animal models of anxiety, depression and psychosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Joshi, M. Akhtar, M. Najmi, A. K. Khuroo, A. H. Goswami, D.
Description	Country affiliation: India Author Affiliation: Joshi M ( Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India.)
Abstract	The role of zinc (Zn) in anxiety, depression and psychosis was studied in rodents. Zn was administered at doses of 15 and 20 mg/kg intraperitoneally for 7 days. Both doses of Zn reduced the immobility time and increased the swimming time in the modified forced swim test. In the elevated plus maze test, increases in the number of open arm entries and time spent in the open arms were observed with both doses of Zn. In the amphetamine (1 and 2 mg/kg subcutaneously) induced locomotor activity test both doses of Zn produced reduction in the total movement time, mean velocity and stereotypic movements. Extrapyramidal symptoms such as catalepsy in animals are usually observed with conventional antipsychotic agents; but in the present study, Zn at doses of 15 and 20 mg/kg did not produce any cataleptic state in mice. The results of the present study demonstrated the anxiolytic, antidepressant and antipsychotic-like effects of Zn metal ion, which may be due to its N-methyl d-aspartate receptor antagonistic activity. Concurrent administration of a lower dose of Zn with standard existing anxiolytic and antidepressant drugs in this study showed potentiating effect, suggesting that Zn could exert beneficial role when prescribed as add-on medicine in the psychiatric illnesses. The results obtained in this study are preliminary, as further research is required to confirm the exact role of Zn metal in the investigated central nervous system disorders.
File Format	HTM / HTML
ISSN	09603271
Issue Number	12
Volume Number	31
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2012-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Anxiety Drug Therapy Behavior, Animal Drug Effects Central Nervous System Agents Pharmacology Chlorides Depression Psychotic Disorders Zinc Compounds Animals Disease Models, Animal Drug Synergism Drug Therapy, Combination Freezing Reaction, Cataleptic Haloperidol Toxicity Injections, Intraperitoneal Male Maze Learning Mice Motor Activity Rats Rats, Wistar Swimming Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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