NDLI: Effect of recombinant human erythropoietin on mitomycin C-induced oxidative stress and genotoxicity in rat kidney and heart tissues.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rjiba-Touati, K. Ayed-Boussema, I. Guedri, Y. Achour, A. Bacha, H. Abid-Essefi, S.
Description	Country affiliation: Tunisia Author Affiliation: Rjiba-Touati K ( Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.); Ayed-Boussema I ( Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.); Guedri Y ( Department of Nephrology, Dialysis and Transplant, University Hospital of Sahloul, Sousse, Tunisia.); Achour A ( Department of Nephrology, Dialysis and Transplant, University Hospital of Sahloul, Sousse, Tunisia.); Bacha H ( Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia hassen.bacha@fmdm.rnu.tn.); Abid-Essefi S ( Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.)
Abstract	Mitomycin C (MMC) is an antineoplastic agent used for the treatment of several human malignancies. Nevertheless, the prolonged use of the drug may result in a serious heart and kidney injuries. Recombinant human erythropoietin (rhEPO) has recently been shown to exert an important cytoprotective effect in experimental brain injury and ischemic acute renal failure. The aim of the present work is to investigate the cardioprotective and renoprotective effects of rhEPO against MMC-induced oxidative damage and genotoxicity. Our results showed that MMC induced oxidative stress and DNA damage. rhEPO administration in any treatment conditions decreased oxidative damage induced by MMC. It reduced malondialdehyde and protein carbonyl levels. rhEPO ameliorated reduced glutathione plus oxidized glutathione modulation and the increased catalase activity after MMC treatment. Furthermore, rhEPO restored DNA damage caused by MMC. We concluded that rhEPO administration especially in pretreatment condition protected rats against MMC-induced heart and renal oxidative stress and genotoxicity.
File Format	HTM / HTML
ISSN	09603271
Issue Number	1
Volume Number	35
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Erythropoietin Pharmacology Heart Drug Effects Kidney Mitomycin Adverse Effects Oxidative Stress Alkylating Agents Animals Catalase Metabolism Comet Assay Dna Damage Drug Administration Schedule Glutathione Lipid Peroxidation Male Mutagenicity Tests Myocardium Protein Carbonylation Rats Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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