NDLI: Measurement of cholinesterase enzyme activity before and after exposure to organophosphate pesticides in farmers of a suburb region of Mazandaran, a northern province of Iran.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pakravan, N. Shokrzadeh, M. Bari, M. A. Khalat Shadboorestan, Amir
Spatial Coverage	Iran
Description	Author Affiliation: Pakravan N ( Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran.); Shokrzadeh M ( Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran mslamuk@yahoo.com.); Bari MA ( Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran.); Shadboorestan A ( Department of Toxicology and Pharmacology, Faculty of Pharmacy,Tehran University of Medical Sciences, Tehran, Iran.)
Abstract	INTRODUCTION: Accidental toxicity by organophosphate (OP) agents may occur among farmers during spraying season due to improper use and handling. Plasma cholinesterase (ChE) activity measurement is recommended to monitor the extent of exposure to the OP agent. The aim of the current study was to measure plasma ChE activity before and after exposure with OP pesticides. METHODS: This was a prospective study conducted on 36 farmers working in the farm field. The plasma ChE level was measured before spraying and 2 days and 8 weeks after spraying season and exposure to OP agent. Farmers were observed for clinical signs and symptoms of toxicity after exposure. RESULTS: Vertimac was the most common agent used by farmers followed by diazinon and chlorpyrifos. The plasma ChE level significantly decreased after exposure by over 50%. The level returned to preexposure level after 8 weeks. CONCLUSION: Exposure to OP pesticide is a major concern in the developing countries. More than 50% reduction in the plasma ChE activity after spraying is an alarming message for health-care system and policy makers. Furthermore, workplace evaluation, serial ChE monitoring, and appropriate training and education to exposed individuals would be initial important steps to avoid the toxicity or reduce the severity of poisoning.
File Format	HTM / HTML
ISSN	09603271
Issue Number	3
Volume Number	35
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2016-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Cholinesterase Inhibitors Toxicity Cholinesterases Blood Insecticides Organophosphorus Compounds Adult Aged Aged, 80 And Over Farmers Humans Iran Epidemiology Male Middle Aged Occupational Exposure Adverse Effects Prospective Studies Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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