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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Watanabe, Takao Konishi, Ichiro Shigematsu, Shuichiro Uesugi, Kazuhiro Joko, Kouji Seike, Hirotaka Okada, Shinichi Miyaoka, Hiroaki Nakanishi, Seiji Abe, Masanori Matsuura, Bunzo Michitaka, Kojiro Horiike, Norio Hiasa, Yoichi Onji, Morikazu |
| Description | Country affiliation: Japan Author Affiliation: Watanabe T ( Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon Department of Gastroenterology, Ehime Prefectural Central Hospital Center for Liver-Biliary-Pancreatic Diseases, Matsuyama Red Cross Hospital Department of Internal Medicine, Saiseikai Matsuyama Hospital, Matsuyama Department of Internal Medicine, Uwajima City Hospital, Uwajima Department of Internal Medicine, Saiseikai Saijo Hospital, Saijo Department of Internal Medicine, Ehime Prefectural Imabari Hospital Department of Internal Medicine, Saiseikai Imabari Daini Hospital, Imabari, Japan.) |
| Abstract | AIM: Patients infected with hepatitis C virus (HCV) genotype 2 are more sensitive to interferon (IFN) therapy than those infected with genotype 1, but 10-20% of patients do not achieve a sustained viral response (SVR) to combination therapy with pegylated (PEG) IFN and ribavirin (RBV). This study examines the prognostic factors associated with SVR in patients infected with HCV genotype 2 treated with PEG IFN and RBV. METHODS: We treated 149 patients with chronic hepatitis C caused by HCV genotype 2. The patients received s.c. PEG IFN- -2b (1.5 µg/kg) and a weekly weight-adjusted dose of RBV (600, 800 and 1000 mg per <60, 60-80 and >80 kg, respectively) for 24 weeks and then prognostic factors associated with the SVR were examined. RESULTS: Among the 149 patients, 138 completed the combination therapy and a sustained viral response was achieved in 71.8% of them. Univariate analysis showed that age, as well as mean RBV and PEG IFN doses were factors affecting the SVR (P = 0.012, =0.021, =0.014). Multivariate analysis identified age and mean PEG IFN dose (P = 0.021, =0.018, respectively) as factors involved in the SVR, but not mean RBV dose. CONCLUSION: The SVR of patients infected with HCV genotype 2 depended on the dosage of PEG IFN, but not of RBV. Selecting sufficient doses of PEG IFN for combination with RBV is critical for treating such patients. |
| File Format | HTM / HTML |
| ISSN | 13866346 |
| Issue Number | 8 |
| Journal | Hepatology Research |
| Volume Number | 41 |
| e-ISSN | 1872034X |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2011-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Hepatology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Hepatology |
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